Furazolidone-induced pulmonary toxicity in Helicobacter pylori infection:Two case reports  

作　　者：Yao Ye Zi-Ling Shi Zhuo-Chao Ren Yi-Lan Sun 

机构地区：[1]Geriatric Medicine Center,Department of Pulmonary and Critical Care Medicine,Zhejiang Provincial People’s Hospital,Affiliated People’s Hospital,Hangzhou Medical College,Hangzhou 310014,Zhejiang Province,China [2]Graduate School of Clinical Medicine,Bengbu Medical College,Bengbu 233000,Anhui Province,China

出　　处：《World Journal of Clinical Cases》2023年第12期2832-2838,共7页世界临床病例杂志

摘　　要：BACKGROUND Helicobacter pylori(H.pylori)infection is a global problem,causing significant morbidity and mortality.Furazolidone is recommended to eradicate H.pylori infections in China owing to the highly associated antibiotic resistance.CASE SUMMARY This article presents two cases of lung injury caused by furazolidone treatment of H.pylori infection and the relevant literature review.Two patients developed symptoms,including fever,cough,and fatigue after receiving a course of furazolidone for H.pylori infection.Chest computed tomography showed bilateral interstitial infiltrates.Laboratory studies revealed elevated blood eosinophil count.After discontinuing furazolidone with or without the use of corticosteroids,the symptoms improved rapidly.A PubMed database literature search revealed three reported cases of lung injury suggestive of furazolidone-induced pulmonary toxicity.CONCLUSION Clinicians should be aware of the side effects associated with the administration of furazolidone to eradicate H.pylori infection.

关 键 词：FURAZOLIDONE Helicobacter pylori infection Pulmonary hypersensitivity Case report 

分 类 号：R573.1[医药卫生—消化系统]