Targeting the m6A mRNA demethylase FTO suppresses vascular endothelial growth factor release and choroidal neovascularization  

作　　者：Shao-bin Wang Yosuke Nagasaka Dionne Argyle Ayami Nagasaka Praveen Yerramothu Bradley DGelfand Jayakrishna Ambati 

机构地区：[1]Center for Advanced Vision Science,University of Virginia School of Medicine,Charlottesville,VA,USA [2]Department of Ophthalmology,University of Virginia School of Medicine,Charlottesville,VA,USA [3]Department of Biomedical Engineering,University of Virginia School of Medicine,Charlottesville,VA,USA [4]Department of Pathology,University of Virginia School of Medicine,Charlottesville,VA,USA [5]Department of Microbiology,Immunology,and Cancer Biology,University of Virginia School of Medicine,Charlottesville,VA,USA

出　　处：《Signal Transduction and Targeted Therapy》2023年第3期905-907,共3页信号转导与靶向治疗（英文）

基　　金：J.A.has received support from the UVA Strategic Investment Fund,National Institutes of Health(NIH)grants(R01EY028027,R01EY029799,R01EY031039,R01AG082108);DuPont Guerry,III,Professorship,and a gift from Mr.and Mrs.Eli W.Tullis,S.B.W has received support from Annette Lightner Fund(Annette Lightner Research Award),B.D.G.has received support from NIH grants(R01EY028027,R01EY031039,R01EY032512,R01AG082108);BrightFocus Foundation Award M2020114,and the Owens Family Foundation.

摘　　要：Dear Editor,Vascular endothelial growth factor-A(VEGFA,also known as VEGF)is a critical angiogenic factor that regulates the physiological and pathological blood vessel growth.1 Increased abundance of VEGF in the eye underlies many forms of aberrant ocular angiogenesis and resultant vision loss,including in neovascular age-related macular degeneration(nvAMD),proliferative diabetic retinopathy(PDR).

关 键 词：DEGENERATION OCULAR RELEASE 

分 类 号：R543[医药卫生—心血管疾病]