Can visceral fat parameters based on computed tomography be used to predict occult peritoneal metastasis in gastric cancer?  

作　　者：Li-Ming Li Lei-Yu Feng Chen-Chen Liu Wen-Peng Huang Yang Yu Peng-Yun Cheng Jian-Bo Gao 

机构地区：[1]Department of Radiology,Henan Key Laboratory of Imaging Diagnosis and Treatment for Digestive system Tumor,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China [2]Department of Cardiology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China [3]Department of Radiology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China [4]Department of Nuclear Medicine,Peking University First Hospital,Beijing 100034,China [5]Beijing Branch,Siemens Healthineers Ltd.,Shenyang 110011,Liaoning Province,China

出　　处：《World Journal of Gastroenterology》2023年第15期2310-2321,共12页世界胃肠病学杂志（英文版）

基　　金：Supported by Henan Province 2023 Scientific Research Projects Focused on Higher Education Project,China,No.23A320059.

摘　　要：BACKGROUND The preoperative prediction of peritoneal metastasis(PM)in gastric cancer would prevent unnecessary surgery and promptly indicate an appropriate treatment plan.AIM To explore the predictive value of visceral fat(VF)parameters obtained from preoperative computed tomography(CT)images for occult PM and to develop an individualized model for predicting occult PM in patients with gastric carcinoma(GC).METHODS A total of 128 confirmed GC cases(84 male and 44 female patients)that underwent CT scans were analyzed and categorized into PM-positive(n=43)and PM-negative(n=85)groups.The clinical characteristics and VF parameters of two regions of interest(ROIs)were collected.Univariate and stratified analyses based on VF volume were performed to screen for predictive characteristics for occult PM.Prediction models with and without VF parameters were established by multivariable logistic regression analysis.RESULTS The mean attenuations of VF_(ROI 1)and VF_(ROI 2)varied significantly between the PM-positive and PMnegative groups(P=0.044 and 0.001,respectively).The areas under the receiver operating characteristic curves(AUCs)of VF_(ROI 1)and VF_(ROI 2)were 0.599 and 0.657,respectively.The mean attenuation of VF_(ROI 2)was included in the final prediction combined model,but not an independent risk factor of PM(P=0.068).No significant difference was observed between the models with and without mean attenuation of VF(AUC:0.749 vs 0.730,P=0.339).CONCLUSION The mean attenuation of VF is a potential auxiliary parameter for predicting occult PM in patients with GC.

关 键 词：Gastric carcinoma Peritoneal metastasis Visceral fat Tomography X-ray computed Prediction Individualized model 

分 类 号：R735[医药卫生—肿瘤] R730.44[医药卫生—临床医学]