抗VEGF注射治疗对息肉状脉络膜血管病变患者脉络膜新生血管的抑制作用观察  

Observation on the inhibitory effects of anti⁃VEGF injection on choroidal neovascularization in the patients with polypoid choroidal vasculopathy

作　　者：刘炳乾[1] 卢百阳[1] 王雪[1] 姜海涛[1] Liu Bingqian;Lu Baiyang;Wang Xue;Jiang Haitao(Department of Ophthalmology,Lianyungang First People’s Hospital,Lianyungang 222000,China)

机构地区：[1]连云港市第一人民医院眼科,江苏连云港222000

出　　处：《海军医学杂志》2023年第4期392-396,共5页Journal of Navy Medicine

基　　金：江苏省科技项目(BE2020670);江苏省卫生健康委科研项目(H2019109)。

摘　　要：目的观察抗血管内皮生长因子(VEGF)注射治疗对息肉状脉络膜血管病变(PCV)患者脉络膜新生血管的远期抑制作用。方法选取2017年3月至2018年12月于连云港市第一人民医院眼科接受治疗的200例(216只眼)PCV患者为研究对象,均接受玻璃体腔抗VEGF注射治疗,行最佳矫正视力(BCVA)检查、间接检眼镜检查、眼压检查、吲哚菁绿血管造影(ICGA)检查、荧光素眼底血管造影(FFA)检查及黄斑前膜多焦视网膜电图(mfERG)检查。观察比较治疗前及治疗后不同时间段最小分辨角对数视力(logMAR)、眼压、中心凹视网膜厚度(CFT)、黄斑中心凹视网膜厚度(CRT)、BCVA及mfERG值。结果患者治疗后7 d、3个月、1年logMAR值明显低于治疗前。治疗后3个月、1年logMAR值明显低于治疗后7 d,治疗后1年logMAR值明显低于治疗后3个月,差异有统计学意义(P<0.05);治疗前后眼压比较差异无统计学意义(P>0.05);患者治疗7 d、3个月、1年CFT及CRT明显低于治疗前。治疗后3个月、1年CFT及CRT明显低于治疗后7 d,且治疗后CFT及CRT明显低于治疗后3个月,差异有统计学意义(P<0.05)。病程2周~6个月患者治疗前CRT明显高于病程6个月~2年患者,BCVA低于病程6个月~2年患者。治疗后CRT低于病程6个月~2年患者,BCVA低于病程6个月~2年患者,差异有统计学意义(P<0.05)。治疗后7 d的Ring1、Ring2、Ring4、Ring5值及治疗后3个月和1年的Ring1、Ring2、Ring3、Ring4、Ring5值明显高于治疗前,差异有统计学意义(P<0.05);治疗后1年的Ring1、Ring2、Ring3、Ring4、Ring5值明显高于治疗后7 d和3个月,差异有统计学意义(P<0.05)。结论抗VEGF注射治疗能有效恢复PCV患者视力,且对PCV患者脉络膜新生血管具有较强的抑制作用。Objective To observe the long⁃term effects of anti⁃vascular endothelial growth factor(VEGF)injection on choroidal neovascularization in the patients with polypoid choroidal vasculopathy(PCV).Methods A total of 200 patients(216 eyes)with PCV who received treatment in the hospital from March 2017 to December 2018 were selected as research subjects.All the patients received intravitreal injection of anti⁃VEGF.Such examinations as best corrected vision acuity(BCVA),indirect ophthalmoscopy,intraocular pressure,indocyanine green angiography(ICGA),fluorescein fundus angiography(FFA),and macular premembrane multifocal electroretinography(mfERG)were performed.The minimum resolution Angle logarithmic visual acuity(logMAR),intraocular pressure,foveal retinal thickness(CFT),central retinal thickness(CRT),BCVA and mfERG values were observed and compared at different time periods before and after treatment.Results The logMAR values 7 days,3 months and 1 year after treatment were significantly lower than those before treatment,and the logMAR values 3 months and 1 year after treatment were significantly lower than those 7 days after treatment,and the logMAR values 1 year after treatment were significantly lower than those 3 months after treatment,with statistical significance(P<0.05).The CFT and CRT levels 7 days,3 months and 1 year after treatment were significantly lower than those before treatment.The CFT and CRT levels 3 months and 1 year after treatment were significantly lower than those 7 days after treatment,and these same indexes after treatment were significantly lower than those 3 months after treatment,with statistical significance(P<0.05).Before treatment,the CRT level of the patients with a disease course of 2 weeks to 6 months were significantly higher than those of the patients with a disease course of 6 months to 2 years.After treatment,the CRT level of the patients was lower than that of the patients with a disease course of 6 months to 2 years,and the BCVA level was lower than that of the patients with a

关 键 词：血管内皮生长因子 息肉状脉络膜血管病变 脉络膜新生血管 疗效 

分 类 号：R779.6[医药卫生—眼科]