紫杉醇联合表阿霉素新辅助化疗对三阴性乳腺癌患者血清学指标的影响  

Effect of Paclitaxel Combined with Epirubicin Neoadjuvant Chemotherapy on Serum Indexes in Patients with Triple Negative Breast Cancer

作　　者：温国华 李燕玲[1] WEN Guohua;LI Yanling(The Fourth Affiliated Hospital of Guangzhou Medical University/Zengcheng People's Hospital of Guangzhou,Guangzhou 511300,Guangdong,China)

机构地区：[1]广州医科大学附属第四医院/广州市增城区人民医院,广东广州511300

出　　处：《中国药物滥用防治杂志》2023年第3期501-504,共4页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探讨紫杉醇联合表阿霉素新辅助化疗在三阴性乳腺癌(TNBC)患者中的效果。方法:选取2019年7月—2020年7月本院收治的94例TNBC患者,按随机数字表法分为对照组、研究组,每组47例。对照组予以环磷酰胺+表阿霉素化疗,研究组给予紫杉醇+表阿霉素新辅助化疗,比较两组临床疗效、血清学指标[血管内皮生长因子(VEGF)、内皮素(ET)、缺氧诱导因子(HIF-1α)]及不良反应发生情况。结果:研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05);研究组VEGF、ET、HIF-1α低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:紫杉醇与表阿霉素新辅助化疗在TNBC患者治疗中效果确切,能够改善血清学指标,安全可行。Objective:To investigate the effect of paclitaxel combined with epirubicin neoadjuvant chemotherapy in patients with triple negative breast cancer(TNBC).Methods:A total of 94 patients with TNBC admitted to our hospital from July 2019 to July 2020 were randomly divided into control group and study group,47 cases in each group.The control group was treated with cyclophosphamide+epirubicin chemotherapy,and the study group was treated with paclitaxel+epirubicin neoadjuvant chemotherapy.The clinical eficacy,serological indexes[vascular endothelial growth factor(VEGF),endothelin(ET),hypoxia-inducible factor(HIF-1a)]and adverse reactions of the two groups were compared.Results:The total effective rate of treatment in the study group was higher than that in the control group,and the difference was statistically significant(P<0.05).VEGF,ET,HIF-1αin the study group were lower than those in the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Paclitaxel and epirubicin neoadjuvant chemotherapy are effective in the treatment of TNBC patients.They can improve the serological indicators and are safe and feasible.

关 键 词：三阴性乳腺癌 紫杉醇 表阿霉素 血清学指标 

分 类 号：R737.9[医药卫生—肿瘤]