西比灵联合地巴唑治疗血管神经性头痛的临床疗效观察  

Clinical observation of Sibelium combined with Dibazolum in the treatment of angioneurotic headache

作　　者：吴连宝 WU Lian-bao(Department of Neurology,Shenyang 245 Hospital,Shenyang 110000,China)

机构地区：[1]沈阳二四五医院神经内科,110000

出　　处：《中国现代药物应用》2023年第8期112-114,共3页Chinese Journal of Modern Drug Application

摘　　要：目的 分析盐酸氟桂利嗪胶囊(商品名:西比灵)联合地巴唑治疗血管神经性头痛的临床疗效。方法 60例血管神经性头痛患者,以抽签法分为观察组与对照组,各30例。对照组采取西比灵治疗,观察组在对照组基础上加用地巴唑治疗。比较两组患者治疗效果、复发率、头痛和伴随症状改善时间、不良反应发生率及治疗前后血流动力学指标。结果 观察组患者治疗总有效率93.33%明显高于对照组的73.33%,治疗后6个月内复发率3.33%明显低于对照组的20.00%,差异有统计学意义(P<0.05)。观察组患者头痛症状改善时间(3.35±1.00)d及伴随症状改善时间(6.20±1.95)d均短于对照组的(5.68±1.44)、(11.95±2.09)d,差异有统计学意义(P<0.05)。治疗前,两组患者血浆粘度、红细胞比容、纤维蛋白原比较差异无统计学意义(P>0.05);治疗后,观察组患者血浆粘度(1.74±0.10)mPa·s、红细胞比容(42.01±2.47)%、纤维蛋白原(2.92±1.18)g/L均低于对照组的(2.08±0.19)mPa·s、(46.40±2.41)%、(3.55±1.20)g/L,差异有统计学意义(P<0.05)。观察组不良反应发生率为3.33%(1/30),低于对照组的20.00%(6/30),差异有统计学意义(P<0.05)。结论 对血管神经性头痛患者应用西比灵联合地巴唑治疗可显著改善其病情,且治疗安全性有保障,值得进一步推广应用。Objective To analyze the clinical efficacy of flunarizine hydrochloride capsules(trade name:Sibelium)combined with Dibazolum in the treatment of angioneurotic headache.Methods A total of 60 patients with angioneuropathic headache were divided into observation group and control group by lottery method,with 30 cases in each group.The control group was treated with Sibelium,and the observation group was treated with Dibazolum on the basis of control group.Both groups were compared in terms of therapeutic effect,recurrence rate,improvement time of headache and concomitant symptoms,incidence of adverse reactions and hemodynamic indexes before and after treatment.Results The total effective rate in the observation group was 93.33%,which was significantly higher than that of 73.33%in the control group;the recurrence rate of 3.33%within 6 months after treatment in the observation group was significantly lower than that of 20.00%in the control group;the differences were statistically significant(P<0.05).The improvement time of headache symptoms and concomitant symptoms in the observation group were(3.35±1.00)and(6.20±1.95)d,which were shorter than those of(5.68±1.44)and(11.95±2.09)d in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in plasma viscosity,hematocrit and fibrinogen between the two groups(P>0.05).After treatment,the observation group had plasma viscosity of(1.74±0.10)mPa·s,hematocrit of(42.01±2.47)%,fibrinogen of(2.92±1.18)g/L,which were lower than those of(2.08±0.19)mPa·s,(46.40±2.41)%,(3.55±1.20)g/L in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 3.33%(1/30),which was lower than that of 20.00%(6/30)in the control group,and the difference was statistically significant(P<0.05).Conclusion The application of Sibelium combined with Dibazolum in the treatment of patients with angioneurotic headache can significa

关 键 词：血管神经性头痛 盐酸氟桂利嗪胶囊 地巴唑 血流动力学 

分 类 号：R741[医药卫生—神经病学与精神病学]