小肠细菌过度生长的概念变迁及其诊断进展  

Progress on conceptual changes and diagnosis of bacterial overgrowth in the small intestine

作　　者：黄娟(综述) 孙文静(审校) HUANG Juan;SUN Wenjing(Department of Digestive Endocrinology,Chongqing No.13 People′s Hospital,Chongqing 400053,China)

机构地区：[1]重庆市第十三人民医院消化内分泌科,重庆400053

出　　处：《现代医药卫生》2023年第9期1559-1564,共6页Journal of Modern Medicine & Health

基　　金：重庆市卫生健康委员会医学科研项目(2022WSJK033);重庆市第十三人民医院院内医学科研孵化基金项目(2021YNXM04)。

摘　　要：小肠细菌过度生长(SIBO)是指各种原因所致小肠内细菌数量过度增长或菌群种类发生较大改变的现象,该概念于20世纪70年代首次被提出,主要用于描述胃肠手术后患者出现腹痛、腹泻及营养不良的病理、生理机制。随着认识的深入,越来越多的证据表明SIBO与炎症性肠病、肠易激综合征、乳糜泻、脂肪性肝病等消化系统疾病,甚至与糖尿病、肥胖等代谢性疾病有着密切的关系。然而,目前对诊断SIBO的“金标准”及方法尚存在一些争议。该文就SIBO的概念变迁及诊断进行综述。Small intestinal bacterial overgrowth(SIBO)refers to the phenomenon of overgrowth of bacteria in the small intestine and changes of bacterial species caused by various reasons.This concept was first proposed in the 1970s to describe the pathophysiology of abdominal pain,diarrhea and malnutrition in patients after gastrointestinal surgery.With greater understanding,there is growing evidence that SIBO is closely related to digestive diseases such as inflammatory bowel disease,irritable bowel syndrome,celiac disease,fatty liver disease,and even metabolic diseases such as diabetes and obesity.Even more,some metabolic diseases such as diabetes and obesity are associated with SIBO.However,there is some debate about the"gold standard"and method for diagnosing SIBO.This article reviews the conceptual changes and diagnosis of SIBO.

关 键 词：小肠细菌过度生长 十二指肠及空肠吸取物细菌培养 乳果糖氢气甲烷呼气实验 葡萄糖氢气甲烷呼气实验 气体胶囊 小肠采样胶囊 诊断方法 综述 

分 类 号：R574.4[医药卫生—消化系统]