幽门螺杆菌黏附蛋白的结构、功能及其疫苗应用  

Research progresses on the structure of Helicobacter pylori adhesion protein and its vaccine application

作　　者：郭玲 GUO Ling(Chongqing Medical Products Evaluation and Inspection Center,chongqing 401120,China)

机构地区：[1]重庆市药品技术审评查验中心,401120

出　　处：《免疫学杂志》2023年第5期441-446,共6页Immunological Journal

摘　　要：黏附介导的定植与幽门螺杆菌持续感染密切相关。幽门螺杆菌表面的多种黏附蛋白通过识别宿主细胞表面特定的糖结构,表现出对人胃黏膜上皮细胞的特异趋向性。近年来一些黏附蛋白的功能及结构陆续被阐明,不同黏附蛋白识别不同的胃上皮细胞配体,除参与细菌黏附外还与感染导致的慢性炎症、肠上皮化生等免疫病理损伤相关。本文对3种重要的黏附蛋白HpaA、BabA和SabA研究进展进行总结,展望其作为潜在靶点在幽门螺杆菌预防性疫苗研究中的应用。Adhesion-mediated colonization is closely associated with persistent Helicobacter pylori(H.pylori)infection.Various adhesion proteins on the surface of H.pylori exhibit specific tropism towards human gastric mucosal epithelial cells by recognizing specific glycan structures on the host cell surface.In recent years,the functions and structures of some adhesion proteins have been elucidated:different adhesion proteins recognize different gastric epithelial cell ligands and are associated with immunopathological damage such as chronic inflammation and intestinal epithelial chemotaxis due to infection,in addition to their involvement in bacterial adhesion.This review summarizes the progress of research on three important adhesion proteins,HpaA,BabA and SabA,and their application as potential targets in the development of vaccines against of H.pylori.

关 键 词：幽门螺杆菌 黏附 HPAA BabA SabA 

分 类 号：R573.6[医药卫生—消化系统]