内镜下阑尾开口炎与溃疡性结肠炎预后的关系  

Relationship between appendiceal orifice inflammation and prognosis of ulcerative colitis

作　　者：吴雨佳 郭甜甜 陈星 WU Yu-jia;GUO Tian-tian;CHEN Xing(Shanxi Medical University,Taiyuan 030001,China;Department of Gastroenterology in The First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学,030001 [2]山西医科大学第一医院消化内科,030001

出　　处：《现代消化及介入诊疗》2023年第2期151-155,共5页Modern Interventional Diagnosis and Treatment in Gastroenterology

基　　金：山西省重点研发计划项目(201903D321140)。

摘　　要：目的评估阑尾开口炎(appendiceal orifice inflammation,AOI)对溃疡性结肠炎(ulcerative colitis,UC)长期预后的影响。方法回顾性收集2015年10月至2022年10月期间在山西医科大学第二医院及山西省肿瘤医院就诊并接受结肠镜检查的UC病例,使用Kaplan-Meier法计算完全ER、住院治疗和病变近段发展的累积风险,使用Cox比例模型进行多变量分析以研究完全ER(endoscopic remission,ER)累积风险的重要风险因素。结果总共纳入202名UC患者,其中116名伴有AOI。AOI组和非AOI组的除年龄外的一般特征差异无统计学意义。完全ER的累积风险在AOI组和非AOI组之间有显著差异(P=0.033)。AOI组和非AOI组之间的其他疾病结局的累积风险差异无统计学意义(住院,P=0.958;病变近段发展,P=0.078)。多变量Cox回归分析还显示,AOI是UC患者完全ER的重要风险因素(HR,0.465;95%CI,0.221-0.979;P=0.044)。结论AOI与UC患者较低的完全ER率显著相关。因此,建议制定更精确的治疗及随访方案以帮助伴AOI的UC患者达到完全ER。Objective To evaluate the effect of appendiceal originitis(AOI)on the long-term prognosis of ulcerative colitis(UC).Methods Retrospectively collected UC patients who received colonoscopy at the Second Hospital of Shanxi Medical University and Shanxi Cancer Hospital from October 2015 to October 2022,and calculated the cumulative risk of complete ER(endoscopic remission,ER),hospitalization and proximal disease extension using Kaplan-Meier method.Cox proportional model was used to conduct multivariate analysis to study the important risk factors of complete ER.Results A total of 202 UC patients were included,116 of whom were accompanied by AOI.There was no significant difference in general characteristics except age between AOI group and non-AOI group.The cumulative risk of complete ER was significantly different between AOI group and non-AOI group(P=0.033).There was no significant difference in the cumulative risk of other disease outcomes between the AOI group and the non-AOI group(hospitalization,P=0.958;proximal disease extension,P=0.078).Multivariate Cox regression analysis also showed that AOI was an important risk factor for complete ER in UC patients(HR,0.465;95%CI,0.221-0.979;P=0.044).Conclusion AOI is significantly associated with lower complete ER rate in UC patients.Therefore,it is recommended to develop more accurate treatment and follow-up plan to help UC patients with AOI achieve complete ER.

关 键 词：溃疡性结肠炎 阑尾开口炎 跳跃性黏膜损害 内镜下缓解 回顾性分析 

分 类 号：R574.62[医药卫生—消化系统]