肠内营养对结直肠癌放疗并发症及免疫功能的影响研究  

Effects of enteral nutrition on complications and immune function after radiotherapy for colorectal cancer

作　　者：王雪[1] 张蓉[2] 阎春英[2] 牛璐 金燕[2] WANG Xue;ZHANG Rong;YAN Chun-ying;NIU Lu;JIN Yan(Hospital Infection Management Office,Shaanxi Provincial People′s Hospital,Xi′an,710068,Shanxi,China;Department of Gastroenterology,Shaanxi Provincial People′s Hospital,Xi′an,710068,Shanxi,China)

机构地区：[1]陕西省人民医院医院感染管理办公室,710068 [2]陕西省人民医院消化内科,710068

出　　处：《现代消化及介入诊疗》2023年第2期156-159,共4页Modern Interventional Diagnosis and Treatment in Gastroenterology

基　　金：陕西省自然科学基础研究计划项目(2020JQ-944)。

摘　　要：目的探讨肠内营养对结直肠癌放疗并发症及免疫功能的影响。方法选取2020年3月至2022年3月陕西省人民医院收治的结直肠癌放疗病人80例,随机分为肠外营养组(40例)和肠内营养组(40例),肠外营养组采用肠外营养治疗,肠内营养组采用肠内营养治疗。比较治疗后两组病人术后恢复情况和放疗并发症发生情况,治疗前后转铁蛋白(TRF)、白蛋白(ALB)、前白蛋白(PA)、白介素-1(IL-1)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)水平。结果治疗后,肠内营养组首次排气时间、首次排便时间以及住院时间均短于肠外营养组,差异有统计学意义(P<0.05);肠内营养组TRF、ALB、PA水平高于肠外营养组,差异有统计学意义(P<0.05);肠内营养组IL-1、IL-8、TNF-α水平低于肠外营养组,差异有统计学意义(P<0.05);肠内营养组IgA、IgG、IgM水平高于肠外营养组,差异有统计学意义(P<0.05);肠内营养组并发症发生率为10.00%,低于肠外营养组的27.50%,差异有统计学意义(P<0.05)。结论对于结直肠癌放疗病人,采用肠内营养可以缩短术后胃肠功能恢复进程,提高营养状态,抑制炎症反应,增强免疫功能,降低并发症发生率。Objective To explore the effects of enteral nutrition on complications and immune function after radiotherapy for colorectal cancer.Methods A total of 80 patients undergoing colorectal cancer radiotherapy in Shaanxi People′s Hospital were enrolled between March 2020 and March 2022.They were randomly divided into parenteral nutrition group(40 cases,parenteral nutrition)and enteral nutrition group(40 cases,enteral nutrition).The postoperative recovery and radiotherapy complications after treatment,levels of transferrin(TRF),albumin(ALB),prealbumin(PA),interleukin-1(IL-1),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),immunoglobulin A(IgA),immunoglobulin G(IgG)and immunoglobulin M(IgM)before and after treatment were compared between the two groups.Results After treatment,the first exhaust time,the first defecation time and hospitalization time in enteral nutrition group were shorter than those in parenteral nutrition group(P<0.05).The levels of TRF,ALB and PA in enteral nutrition group were higher than those in parenteral nutrition group(P<0.05),levels of IL-1,IL-8 and TNF-αwere lower than those in parenteral nutrition group(P<0.05),levels of IgA,IgG and IgM were higher than those in parenteral nutrition group(P<0.05),and incidence of complications was lower than that in parenteral nutrition group(10.00%vs 27.50%)(P<0.05).Conclusion For patients undergoing colorectal cancer radiotherapy,enteral nutrition can shorten recovery process of gastrointestinal function,improve nutritional status,inhibit inflammatory response,enhance immune function and reduce the incidence of complications.

关 键 词：肠内营养 结直肠癌 放疗 并发症 免疫功能 

分 类 号：R735.3[医药卫生—肿瘤] R574[医药卫生—临床医学]