RGS12 represses oral squamous cell carcinoma by driving M1 polarization of tumor-associated macrophages via controlling ciliary MYCBP2/KIF2A signaling  

作　　者：Gongsheng Yuan Shuting Yang Shuying Yang 

机构地区：[1]Department of Basic and Translational Sciences,School of Dental Medicine,University of Pennsylvania,Philadelphia,USA [2]The Penn Center for Musculoskeletal Disorders,Perelman School of Medicine,University of Pennsylvania,Philadelphia,USA [3]Center for Innovation&Precision Dentistry,Penn Dental Medicine and School of Engineering and Applied Sciences,University of Pennsylvania,Philadelphia,USA

出　　处：《International Journal of Oral Science》2023年第1期148-158,共11页国际口腔科学杂志（英文版）

基　　金：supported by National Institutes of Health(NIH)grants AG048388 and AR066101 to Dr.Shuying Yang;supported by U.S.Department of Defense(DOD)grants PR201467 and RA210159 to Dr.Shuying Yang。

摘　　要：Tumor-associated macrophages(TAMs)play crucial roles in tumor progression and immune responses.However,mechanisms of driving TAMs to antitumor function remain unknown.Here,transcriptome profiling analysis of human oral cancer tissues indicated that regulator of G protein signaling 12(RGS12)regulates pathologic processes and immune-related pathways.Mice with RGS12knockout in macrophages displayed decreased M1 TAMs in oral cancer tissues,and extensive proliferation and invasion of oral cancer cells.RGS12 increased the M1 macrophages with features of increased ciliated cell number and cilia length.Mechanistically,RGS12 associates with and activates MYC binding protein 2(MYCBP2)to degrade the cilia protein kinesin family member 2A(KIF2A)in TAMs.Our results demonstrate that RGS12 is an essential oral cancer biomarker and regulator for immunosuppressive TAMs activation.

关 键 词：INVASION driving RGS 

分 类 号：R739.8[医药卫生—肿瘤]