纳米药物重编程肿瘤相关巨噬细胞增强抗癌效果  

Recent progress of nanoparticle reprogramming of tumor-associated macrophages(TAMs)to enhance anti-tumor activity

作　　者：陈明娃 王俊侠 CHEN Mingwa;WANG Junxia(Guangzhou First People’s Hospital,the Second Affiliated Hospital,South China University of Technology,Guangzhou 510180,China)

机构地区：[1]华南理工大学附属第二医院,广州市第一人民医院,广州510180

出　　处：《广州医药》2023年第4期1-13,共13页Guangzhou Medical Journal

基　　金：国家自然科学基金青年项目(52103160);广东省自然科学基金面上项目(2022A1515010074);广州市科协青年科技人才托举工程(QT20220101146)。

摘　　要：肿瘤相关巨噬细胞(TAMs)是肿瘤微环境中最丰富的免疫细胞之一,M2-TAMs在肿瘤发生、发展、转移和治疗过程中发挥重要作用,被认为是肿瘤治疗中的重要靶点。已有的研究表明,通过将促肿瘤的M2-TAMs重编程为促炎的M1-TAMs可实现抑制肿瘤生长和转移。本综述在介绍TAMs与肿瘤治疗相关背景的基础上,重点关注纳米药物重编程TAMs增强抗肿瘤的研究进展。本文将从TAMs靶向递送各种活性物质进行重编程TAMs和纳米药物介导的异常肿瘤微环境调节的间接重编程TAMs两种方式,综述近年来基于纳米药物递送系统的调控策略及典型例子。Tumor associated macrophages(TAMs)is one of the most abundant immune cells in the tumor microenvironment.M2-TAMs play an important role in tumor genesis,progression,metastasis and treatment,and is additionally a very important target in tumor therapy.Previous studies have shown that inhibition of tumor growth and metastasis can be achieved by reprogramming M2-TAMs to M1-TAMs.On the basis,this review focuses on the analysis progress of nano-drug reprogramming TAMs to boost anti-tumor.In this paper,we reviewed two methods of reprogramming TAMs for targeted delivery of various active substances and indirect reprogramming TAMs for abnormal tumor microenvironment regulation mediated by nanomedicine.The regulatory strategies and typical samples of nanomedicine delivery systems in recent years were summarized.

关 键 词：纳米药物 肿瘤相关巨噬细胞(TAMs) 肿瘤治疗 

分 类 号：R730.5[医药卫生—肿瘤]