Upconversion nanoscopy revealing surface heterogeneity of tumor-secreted extracellular vesicles  

作　　者：Rui Pu Qiuqiang Zhan 

机构地区：[1]Centre for Optical and Electromagnetic Research,South China Academy of Advanced Optoelectronics,South China Normal University,Guangzhou 510006,China

出　　处：《Light(Science & Applications)》2023年第4期502-504,共3页光（科学与应用)（英文版）

基　　金：supported by the National Natural Science Foundation of China(62122028,11974123);Guangdong Basic and Applied Basic Research Foundation(2023B1515040018,2018B030306015,2019A050510037).

摘　　要：Super-resolution microscopic imaging employing upconversion nanoparticles is applied to reveal the surface heterogeneity of tumor cell-derived small extracellular vesicles,i.e.,exosome.The number of surface antigens of every extracellular vesicles can be quantified by both the high imaging resolution and stable brightness of upconversion nanoparticles.This method proves its great potential in nanoscale biological studies.

关 键 词：surface RESOLUTION REVEALING 

分 类 号：R730[医药卫生—肿瘤]