宫颈神经内分泌癌的诊治进展及思考  

Advances and thinking in the diagnosis and treatment of cervical neuroendocrine carcinoma

作　　者：戴冠琳 王丹青 唐芙蓉[1,2] DAI Guanlin;WANG Danqing;TANG Furong(Department of Obstetrics and Gynecology,West China Second Hospital,Sichuan University,Chengdu 610041,China;Key Laboratory of Obstetric&Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education,Chengdu 610041,China)

机构地区：[1]四川大学华西第二医院妇产科,四川成都610041 [2]出生缺陷与相关妇儿疾病教育部重点实验室,四川成都610041

出　　处：《西部医学》2023年第5期625-631,共7页Medical Journal of West China

基　　金：四川省科技厅重点研发项目(2020YFS0131,2016FZ0081);卫生健康发展促进项目(BJHA-CRP-068);新锐肿瘤支持治疗课题研究项目(cphcf-2022-109)。

摘　　要：宫颈神经内分泌癌(NECC)是一种少见且恶性程度极高的肿瘤,相较于宫颈鳞癌及腺癌,更容易早期出现转移和复发。由于其少见性,目前难以开展前瞻性大样本临床试验研究,多为回顾性小样本研究。其治疗策略主要来自回顾性研究及参考小细胞肺癌的治疗方案,目前临床上采用多模式综合治疗,诊断治疗存在一定争议。本文回顾近年来NECC的诊疗进展,总结并思考NECC诊治管理新理念,为该类患者提供最佳的诊治策略。Neuroendocrine cervical carcinoma is a rare and highly malignant tumor that is more likely to present with distant lymph node metastases in early stages and recurrence compared to squamous and adenocarcinoma of the cervix.Due to its rarity,it is currently difficult to carry out prospective large sample clinical trials and most of them are retrospective small sample studies.Its treatment options are mainly extrapolated from limited retrospective studies and those for small cell lung cancer.Multimodal integrated therapy is generally applicated in clinical practice but there are still controversial regarding their diagnosis and treatment protocols.This article reviews advances in the diagnosis and treatment of neuroendocrine cervical carcinoma,summarizes,and considers new findings proposed for the diagnostic and therapeutic protocols of neuroendocrine cervical carcinoma and provides better options for patients whenever possible.

关 键 词：宫颈癌 神经内分泌癌 宫颈神经内分泌癌 多模式综合治疗 

分 类 号：R737.33[医药卫生—肿瘤]