依达拉奉右莰醇联合血管介入术在脑梗死中的效果  

Effect of edaravone dexborneol combined with vascular intervention in the treatment of cerebral infarction

作　　者：王龙海[1] 程波 何其胜[1] 郑丽娜 朱杰 黄志强[1] WANG Longhai;CHENG Bo;HE Qisheng;ZHENG Lina;ZHU Jie;HUANG Zhiqiang(Department of Neurology,Dazhou Hospital of Integrated Traditional Chinese and Western Medicine,Dazhou 635000,Sichuan,China;Department of Neurology,The Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,China)

机构地区：[1]达州市中西医结合医院神经内科,四川达州635000 [2]川北医学院附属医院神经内科,四川南充637000

出　　处：《西部医学》2023年第5期754-758,共5页Medical Journal of West China

基　　金：达州市卫计委科研课题(2018010)。

摘　　要：目的观察依达拉奉右莰醇联合血管介入术治疗脑梗死的临床效果及对神经功能、认知功能、氧化应激水平的影响。方法回顾性抽取2020年7月~2021年7月于达州市中西医结合医院行血管介入术治疗、依达拉奉右莰醇联合血管介入术治疗的患者,分别为对照组和观察组各20例。比较两组患者治疗前后神经功能、认知功能、氧化应激水平及生活质量改善情况,并对治疗后总有效率及所有不良反应进行记录。结果与治疗前比较,两组治疗后美国国立卫生研究院卒中量表(NIHSS)评分、丙二醛(MDA)均明显降低(P<0.001),简易智能量表(MMSE)评分、超氧化合物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-px)均显著升高(P<0.001);治疗后2周、4周脑卒中专用生活质量量表(SS-QOL)评分均显著升高(P<0.001)。治疗后与对照组相比,观察组NIHSS评分、血清MDA明显低,MMSE评分、SOD、GSH-px显著升高,治疗后2周、4周SS-QOL评分显著升高(P<0.001)。观察组总有效率优于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论依达拉奉右莰醇联合血管介入术治疗脑梗死患者,在改善神经认知功能,减轻氧化应激反应等方面均有突出优势,且对提高生活质量也具有重要意义,安全性较好。Objective To observe the clinical effect of edaravone dexborneol combined with vascular intervention in the treatment of cerebral infarction,and the influence on neurological function,cognitive function and oxidative stress level.Methods From July 2020 to July 2021,20 patients in Dazhou integrated traditional Chinese and Western medicine hospital who underwent vascular interventional therapy and edaravone dexcamphenol combined with vascular interventional therapy were selected retrospectively.They were the control group and the observation group respectively.Neurological function,cognitive function,oxidative stress level and quality of life were compared between the two groups before and after treatment.The total response rate and adverse reactions were recorded.Results After treatment,the National Institutes of Health Stroke Scale(NIHSS)scores and malondialdehyde(MDA)were significantly reduced,and the Mini Mental State Examination(MMSE)scores,superoxide dismutase(SOD)and glutathione peroxidase(GSH-px)were significantly increased in the two groups(P<0.05).The Stroke-specific Quality of Life Scale(SS-QOL)scores of the two groups were significantly increased at 2 and 4 weeks after treatment(P<0.05).After treatment,the NIHSS scores and serum MDA level of the observation group were significantly lower,MMSE scores,SOD and GSH-px levels were significantly higher,and the SS-QOL scores at 2 and 4 weeks after treatment were significantly higherthan those of the control group(P<0.05).The total response rate in observation group was better than that in the control group(P<0.05),but there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Edaravone dexborneol combined with vascular intervention for treating patients with cerebral infarction has distinctive advantages in improving neurological function and cognitive function,and relieving oxidative stress,with good safety,which is of great significance for improving quality of life.

关 键 词：依达拉奉右莰醇 血管介入术 脑梗死 神经功能 氧化应激 

分 类 号：R743.3[医药卫生—神经病学与精神病学]