Unlocking G-Quadruplexes as Targets and Tools against COVID-19  

作　　者：Geng Qin Chuanqi Zhao jie Yang Zhao Wang Jinsong Ren Xiaogang Qu 

机构地区：[1]Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization,Changchun Institute of Applied Chemistry ChineseAcademyof Science,Changchun,Jilin 130022 [2]University of Science and Technology of China,Hefei,Anhui 230026,China

出　　处：《Chinese Journal of Chemistry》2023年第5期560-568,共9页中国化学（英文版）

基　　金：Financial support was provided by the National Key R&D Program of China(2019YFA0709202);the National Natural Science Foundation of China(91856205,21820102009,22237006,22107098,22122704);the Key Program of Frontier of Sciences(CAS QYZDJ-SSW-SLHO52).

摘　　要：The applicability of G-quadruplexes(G4s)as antiviral targets,therapeutic agents and diagnostic tools for coronavirus disease 2019(COVID-19)is currently being evaluated,which has drawn the extensive attention of the scientific community.During the COVID-19 pandemic,research in this field is rapidly accumulating.In this review,we summarize the latest achievements and breakthroughs in the use of G4s as antiviral targets,therapeutic agents and diagnostic tools for COVID-19,particularly using G4 ligands.Finally,strength and weakness regarding G4s in anti-SARS-CoV-2 field are highlighted for prospective future projects.

关 键 词：G-QUADRUPLEXES Viruses Nucleic acids Drug discovery Aptamers 

分 类 号：R563.1[医药卫生—呼吸系统]