G-QUADRUPLEXES

作品数：14被引量：18H指数：2
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DNA G-Quadruplexes as Targets for Natural Product Drug Discovery
《Engineering》2024年第7期39-51,共13页Kai-Bo Wang Yingying Wang Jonathan Dickerhoff Danzhou Yang 
supported by the National Institutes of Health(R01CA177585,U01CA240346,and R01CA153821)(DY);the Purdue Center for Cancer Research(P30CA023168);the National Natural Science Foundation of China(82173707 and 82322065);the Program for Jiangsu Province Innovative Research Scholar(JSSCRC2021512);the“Double First-Class”University Project(CPUQNJC22_08).
DNA guanine(G)-quadruplexes(G4s)are unique secondary structures formed by two or more stacked Gtetrads in G-rich DNA sequences.These structures have been found to play a crucial role in highly transcribed genes,especi...
关键词：G-QUADRUPLEX Natural products ALKALOIDS CANCER PROMOTER 
Unfolding rates of 1:1 and 2:1 complex of CX-5461 and c-MYC promoter G-quadruplexes revealed by single-molecule force spectroscopy
《Biophysics Reports》2024年第3期180-189,共10页Hui Peng Yashuo Zhang Qun Luo Xinyu Wang Huijuan You 
financially supported in part by grants from the National Natural Science Foundation of China (32171225)。
CX-5461, also known as pidnarulex, is a strong G4 stabilizer and has received FDA fast-track designation for BRCA1-and BRCA2-mutated cancers. However, quantitative measurements of the unfolding rates of CX-5461-G4 com...
关键词：SINGLE-MOLECULE G-QUADRUPLEX Magnetic tweezers STOICHIOMETRY Force spectroscopy Pidnarulex 
Hierarchical Self-assembly of G-Quadruplexes Based Hydrogel Consisting of Guanine and Peptide Epitope被引量：1
《Chinese Journal of Chemistry》2023年第14期1727-1732,共6页Hongyue Zhang Xuejiao Yang Juan Liang Kaihua Chen Huaimin Wang 
supported by the National Natural Science Foundation of China(82022038)。
Guanosine-based hydrogels have attracted considerable attention because of their simplicity and easy preparation.However,the sugar moiety limits its further applications because of the necessity of sugar in the hydrog...
关键词：G-QUADRUPLEXES Peptides NUCLEOBASES SELF-ASSEMBLY HYDROGELS Cell culture 
Unlocking G-Quadruplexes as Targets and Tools against COVID-19被引量：1
《Chinese Journal of Chemistry》2023年第5期560-568,共9页Geng Qin Chuanqi Zhao jie Yang Zhao Wang Jinsong Ren Xiaogang Qu 
Financial support was provided by the National Key R&D Program of China(2019YFA0709202);the National Natural Science Foundation of China(91856205,21820102009,22237006,22107098,22122704);the Key Program of Frontier of Sciences(CAS QYZDJ-SSW-SLHO52).
The applicability of G-quadruplexes(G4s)as antiviral targets,therapeutic agents and diagnostic tools for coronavirus disease 2019(COVID-19)is currently being evaluated,which has drawn the extensive attention of the sc...
关键词：G-QUADRUPLEXES Viruses Nucleic acids Drug discovery Aptamers 
G-quadruplexes folding mediates downregulation of PBX1 expression in melanoma被引量：1
《Signal Transduction and Targeted Therapy》2023年第2期344-347,共4页Yutong Sui Feilin Liu Song Zheng Xiaomei Liu Pingli Sun Chunli Yao Yingyao Zhang Hongwen Gao Xinghua Gao Jinyu Liu 
We are grateful to the patients and their families for participating in this study.We thank the clinicians,nurses,and study coordinators for their contributions to this work.Prof.H.Y.Zhang(Jilin University)and Dr.M.Li(The First Hospital of Jilin University-the Eastern Division)try their best efforts for Histopathological analysis in this study.Financial support was provided by the China Natural National Science Foundation(82073581);the Jilin Province Science and Technology Development Plan(20190304044YY and 20200801022 GH).
Dear Editor,Pre-B-cell leukemia homeobox transcription factor 1(PBX1)is identified at t(1;19)chromosomal translocations in acute pre-B-cell leukemia and is involved in regulating multiple biological processes.1 Import...
关键词：MELANOMA ACUTE processes 
Enhancing prime editing efficiency by modified pegRNA with RNA G-quadruplexes被引量：10
《Journal of Molecular Cell Biology》2022年第4期65-68,共4页Xiangyang Li Xin Wang Wenjun Sun hisheng Huang Mingtian Zhong Yuan Yao Quanjiang Ji Xingxu Huang 
supported by the Emergency Key Program of Guangzhou Laboratory(EKPG21-18);the Leading Talents of Guangdong Province Program(608285568031).
Dear Editor,Recent study shows that the prime editing system fusing the Cas9 nickase and reverse transcriptase could perform all types ofgene modifications,including basesubstitutions(transitionsand transversions),sma...
关键词：PRIME DONOR TRANSITIONS 
G-quadruplexes in genomes of viruses infecting eukaryotes or prokaryotes are under different selection pressures from hosts被引量：1
《Journal of Genetics and Genomics》2022年第1期20-29,共10页Zhen Li Sheng Hu Qian Fan Wang Hany IMohamed Guangfu Yang Zhen-Xia Chen Dengguo Wei 
supported by the National Natural Science Foundation of China(21732002,22077043,31672558,31871305,21907036);Opening Foundation of State Key Laboratory of Freshwater Ecology and Biotechnology,China(2020FB08);the Fundamental Research Funds for the(2662018PY021,2662019PY003,2662020PY001);Huazhong Agricultural University Scientific&Technological Self-innovation Foundation(2016RC011);HZAU-AGIS Cooperation Fund(SZYJY2021010)。
G-quadruplexes in viral genomes can be applied as the targets of antiviral therapies, which has attracted wide interest. However, it is still not clear whether the pervasive number of such elements in the viral world ...
关键词：G-QUADRUPLEX Selection pressure Database Evolution 
A DNA G-quadruplex converts SOD1 into fibrillar aggregates
《Chinese Chemical Letters》2021年第7期2322-2326,共5页Wenqian Liu Yulin Xu Xue Li Yan Meng Huiling Wang Chunrong Liu Changlin Liu Li Wang 
financially supported by the National Natural Science Foundation of China(Nos.21771073,22077046,21001047,21072074);the Fundamental Research Funds for the Central Universities(No.CCNU19TS052)。
Nucleic acids with G4 elements play a role in the formation of aggregates involved in intracellular phase transitions.Our previous studies suggest that different forms of DNA could act as an accelerating template in C...
关键词：SOD1 Deoxynucleotide oligomers(dN)_(12) G-QUADRUPLEXES Fibrillar aggregates 
Host-Guest Sensor Array for Discriminating G-Quadruplexes被引量：1
《Chemical Research in Chinese Universities》2021年第3期619-620,共2页HU Xinyue GUO Dongsheng 
Rapid classification of the secondary structures of nucleic acids,such as G-quadruplexes(G4s)is desirable but very challenging due to the high similarity among different folding.Chen et al.constructed a host-guest sen...
关键词：SIMILARITY TOPOLOGY desirable 
NDI-induced Topological Conversion of Human Telomeric G-Quadruplexes from Hybrid-2 to Parallel Form
《Chemical Research in Chinese Universities》2021年第3期795-800,共6页HAO Xueyu LI Chunjie WANG Yu ZHANG Feng HOU Jingwei KANG Chunqing GAO Lianxun 
G-Quadruplexes(GQs),which are formed by G-rich DNA sequences in human telomeres,have become an attractive target for cancer treatment.The ligands to stabilize the conformation of human telomeric GQs in vivo are partic...
关键词：G-QUADRUPLEX Naphthalene diimide Topological conversion Telomeric DNA 
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