NT-3对耳蜗螺旋神经节发育的调控机制研究进展  

Research Progress on NT-3 in the Regulation of Spiral Ganglion Neurons Development

作　　者：王雪艳 侯书乐 金永德 孙莲花[2] 贾彦均 权海燕[4] 金玉莲 杨军(审校)[2] WANG Xueyan;HOU Shule;JIN Yongde;SUN Lianhua;JIA Yanjun;QUAN Haiyan;JIN Yulian;YANG Jun;无(Department of Otorhinolaryngology,Head and Neck Surgery,Affiliated Hospital of Yanbian University,Yanji 133000;Department of Otolaryngology-Head&Neck Surgery,Xinhua Hospital,Shanghai Jiaotong University School of Medicine,Shanghai Jiaotong University School of Medicine Ear Institute,Shanghai Key Laboratory of Translational Medicine on Ear and Nose Disease,Shanghai,200092;Department of Otorhinolaryngology,Head and Neck Surgery,Qingdao Central Hospital,Qingdao 266000;Central Laboratory,Affiliated Hospital of Yanbian University,Yanji 133000)

机构地区：[1]延边大学附属医院耳鼻咽喉头颈外科,延吉133000 [2]上海交通大学医学院附属新华医院耳鼻咽喉-头颈外科、上海交通大学医学院耳科学研究所、上海耳鼻疾病转化医学重点实验室,上海200092 [3]青岛市中心医院耳鼻咽喉头颈外科,青岛266000 [4]延边大学附属医院中心实验室,延吉133000

出　　处：《中华耳科学杂志》2023年第2期262-266,共5页Chinese Journal of Otology

基　　金：国家自然科学基金地区基金项目(81860189)。

摘　　要：耳蜗螺旋神经元(spiral ganglion neurons,SGN)的存活和增殖依赖于各种神经营养因子的调节。SGN的损伤和发育异常均可导致感音神经性耳聋,但SGN无再生能力,听力下降往往很难恢复。因此,对听力下降进行早期干预,防止其不可逆的损伤尤为重要。神经营养素3(neurotrophin-3,NT-3)在耳蜗中高表达并促进SGN的存活、轴突的生长和损伤的修复,这已得到广泛的共识,但对其如何将信息传递到细胞内,从而调节SGN的发育仍然不清楚。本文就NT-3在SGN发育期中作用机制的研究进展作一综述。The survival and proliferation of spiral ganglion neurons(SGNs)depend on the regulation by various neurotrophic factors.Damage and developmental abnormalities of SGNs can lead to sensorineural deafness,which is often difficult to recover due to SGNs having no regenerative ability.Early intervention is therefore important to prevent irreversible damage.There is broad consensus that neurotrophin-3(NT-3)is expressed in the cochlea and promotes SGN survival,axon growth and repair,but it remains unclear how it transmits information into cells to regulate SGN development.In this paper,we review the progress in research on neurotrophin-3 and its mechanisms of action during the development of spiral ganglion neurons.

关 键 词：NT-3 TrkC受体 SGN 发育 MAPK信号通路 

分 类 号：R764[医药卫生—耳鼻咽喉科]