一种新型氢化诺卜基双子季铵盐的合成及其抑菌活性研究  

The Synthesis and Antimicrobial Activity of a Novel Hydronopki Quaternary Ammonium Salt

作　　者：昌家宇 肖转泉[2] 罗海 范国荣[1] 陈尚钘[1] 张骥 廖圣良[1] 王宗德 CHANG Jiayu;XIAO Zhuanquan;LUO Hai;FAN Guorong;CHEN Shangxing;ZHANG Ji;LIAO Shengliang;WANG Zongde(College of Forestry,East China Woody Fragrance&Flavvor Engineering Technology Research Center of National Forestry and Grassland Administration,Jiangxi Agricultural University,Nanchang Jiangxi 330045,China;College of Chemistry and Chemical Engineering,Jiangxi Normal University,Nanchang Jiangxi 330022,China)

机构地区：[1]江西农业大学林学院,国家林业草原木本香料(华东)工程技术研究中心,江西南昌330045 [2]江西师范大学化学化工学院,江西南昌330022

出　　处：《江西师范大学学报（自然科学版）》2023年第2期164-167,共4页Journal of Jiangxi Normal University(Natural Science Edition)

基　　金：国家自然科学基金(31960295);江西省主要学科学术和技术带头人培养计划领军人才课题(20204BCJ22022);江西省林业局樟树研究专项课题(2020CXZX07);南昌市“双百计划”人才课题(洪科字〔2020〕137号)资助项目。

摘　　要：该文首先由N,N-二甲基乙醇胺与己二酸反应合成己二酸二(β-二甲胺基)乙酯,然后将己二酸二(β-二甲胺基)乙酯与氢化诺卜基溴按物质的量比例为1.0∶2.1进行反应,合成一种含二元酸酯基的氢化诺卜基双子季铵盐.产物结构用红外光谱、核磁共振(氢谱、碳谱)和质谱进行表征,用菌丝生长速率法评价了该季铵盐化合物对10种植物病原真菌的生长抑制作用.实验结果表明:当药液质量浓度为100.0 mg•L^(-1)时,该季铵盐化合物对松枯梢病病原菌、烟草黑胫病病原菌、彩绒革盖菌和七叶树壳梭孢菌的抑制率达97.0%~100.0%,远高于百菌清的抑制率,对水稻纹枯病病原菌的抑制率接近90.0%;当药液质量浓度为50.0 mg•L^(-1)时,该季铵盐化合物对以上5种病原菌的抑制率分别为100.0%、88.8%、86.8%、84.4%和77.2%,均超过对照样百菌清的抑制率.Bis(β-dimethylamine)ethyl adipate is synthesized by the reaction of N,N-dimethylethanolamine with adipic acid.The latter reacts with hydronopyl bromide(molar ratio 1.0∶2.1)to synthesize a hydronopyl bisquaternary ammonium salt containing diacid ester group.The structure of the product is characterized by IR,NMR(H,C)and MS.The results show that when the concentration of the solution is 97.0%—100.0 mg•L^(-1),the inhibition rate against the pathogen of pine shoot dieback and tobacco black shack is 100.0%,and the inhibition rate against the pathogen of rice sheath blight is close to 90.0%.When the concentration of the liquid is 50 mg•L^(-1),the inhibition rates of the above five pathogens are 100.0%,88.8%,86.8%,84.4%and 77.2%,respectively,which are more than the same chlorothalonil.

关 键 词：二元酸酯 氢化诺卜基 双子季铵盐 合成 抑菌活性 

分 类 号：O621[理学—有机化学] TQ463[理学—化学]