游离脂肪酸受体在神经系统疾病中作用的研究进展  

Research progress on role of free fatty acid receptors in nervous system diseases

作　　者：刘伟(综述)[1] 赵翀翀(审校)[1] LIU Wei;ZHAO Chongchong(Neurology Department,Lanzhou University Second Hospital,Lanzhou 730030,Gansu Province,China)

机构地区：[1]兰州大学第二医院神经内科,甘肃兰州730030

出　　处：《中国生物制品学杂志》2023年第4期478-482,488,共6页Chinese Journal of Biologicals

基　　金：甘肃省自然科学基金(20JR5RA330)。

摘　　要：游离脂肪酸受体(free fatty acid receptors,FFARs)是一系列由游离脂肪酸(free fatty acids,FFAs)及其衍生物激活的孤儿G蛋白偶联受体(G protein-coupled receptors,GPCRs)。GPCRs作为跨膜受体,参与了多种疾病的发生发展过程,为这些疾病提供了广泛的治疗靶点。FFARs结合FFAs后主要参与胰岛素等内分泌激素分泌、脂肪细胞分化、炎症反应、自身免疫反应等过程,是能量代谢紊乱和免疫疾病的潜在治疗靶点。但近年研究表明,FFAs及其受体FFARs还可直接或通过脑-肠轴广泛参与神经炎症、神经免疫等反应,有望成为多发性硬化、阿尔茨海默病(Alzheimer’s disease,AD)、帕金森病(Parkinson’s disease,PD)、抑郁症等疾病治疗的靶点。本文就FFARs在神经系统疾病中作用的研究进展作一综述。Free fatty acid receptors(FFARs)are a series of orphan G protein-coupled receptors(GPCRs)activated by free fatty acids(FFAs)and their derivatives.As transmembrane receptors,GPCRs are involved in the occurrence and development of many diseases and provide a wide range of therapeutic targets for these diseases.FFARs combined with FFAs are mainly involved in the secretion of endocrine hormones such as insulin,adipocyte differentiation,inflammatory response,autoimmune response and other processes,which was a potential therapeutic target for energy metabolism disorders and immune diseases.However,recent studies have shown that FFAs and its receptor FFARs are widely involved in neuroinflammation and neuroimmunity directly or through the brain-intestinal axis,and are expected to be a therapeutic target for multiple sclerosis,Alzheimer′s disease(AD),Parkinson′s disease(PD),depression and other diseases.This paper reviews the research progress of the role of FFARs in nervous system diseases.

关 键 词：游离脂肪酸 游离脂肪酸受体 G蛋白偶联受体 神经系统疾病 

分 类 号：R741[医药卫生—神经病学与精神病学]