膀胱低度恶性潜能乳头状尿路上皮肿瘤患者经尿道膀胱肿瘤电切术预后影响因素  

Influencing Factors of Clinical Prognosis in Patients With Papillary Urothelial Neoplasm of Low Malignant Potential After Transurethral Resection of Bladder Tumor

作　　者：荆文 张珑[1] 王伟[1] 吴涛[1] JING Wen;ZHANG Long;WANG Wei;WU Tao(Department of Urology,The First Hospital of Handan City,Hebei Handa 056002,China)

机构地区：[1]邯郸市第一医院泌尿二科,河北邯郸056002

出　　处：《循证医学》2022年第5期291-294,共4页The Journal of Evidence-Based Medicine

摘　　要：目的探讨膀胱低度恶性潜能乳头状尿路上皮肿瘤(papillary urothelial neoplasm of low malignant potential,PUNLMP)患者经尿道膀胱肿瘤电切术(transurethral resection of bladder tumor,TURBT)预后的影响因素。方法回顾性分析邯郸市第一医院2013年1月至2019年12月收治接受TURBT术治疗的膀胱PUNLMP患者共170例,单因素和多因素logistic回归分析患者TURBT术预后的影响因素。结果术后随访6.5~92.0个月,中位随访时间27.0个月,无肿瘤相关性死亡事件发生。42例肿瘤复发,复发时间2.5~87.5个月,中位复发时间24.0个月。24例进展,进展时间3.0~58.0个月,中位进展时间为23.5个月。单因素分析结果表明初发肿瘤最大径和数量与TURBT术后复发和进展有关。多因素logistic回归分析结果显示,初发肿瘤数量是PUNLMP患者TURBT术后复发和进展的独立影响因素(P<0.05)。结论初发肿瘤数量与膀胱PUNLMP患者TURBT术的预后密切相关;术后膀胱灌注化疗无法改善此类患者临床预后。Objective To investigate the influencing factors of clinical prognosis in patients with papillary urothelial neoplasm of low malignant potential(PUNLMP)after transurethral resection of bladder tumor(TURBT).Methods Clinical data of 170 patients with low malignant potential bladder PUN after TURBT were retrospectively chosen from January 2013 to December 2019 in The First Hospital of Handan City.Univariate and multivariate methods were used to evaluate the influencing factors of clinical prognosis after TURBT.Results The patients were followed up for 6.5 to 92.0 months with a median time of 27.0 months and no tumor⁃related death occurred.42 patients had tumor recurrence,the recurrence time was 2.5~87.5 months,and the median recurrence time was 24.0 months.24 cases with progression,with the median progression time of 23.5 months ranging from 3.0 to 58.0 months.Univariate analysis showed that the maximum diameter and number of primary tumors were related to the recurrence and progression after TURBT.Multivariate analysis showed that the number of primary tumors was the independent factor affecting the recurrence and progression of bladder PUN patients with low malignant potential after TURBT(P<0.05).Conclusions The number of primary tumors is closely related to the clinical prognosis of bladder PUN patients with low malignant potential after TURBT and postoperative intravesical chemotherapy should not improve the clinical prognosis of patients.

关 键 词：膀胱肿瘤 低度恶性潜能乳头状尿路上皮肿瘤 经尿道膀胱肿瘤电切术 临床预后 影响因子 

分 类 号：R737.14[医药卫生—肿瘤]