三七通舒胶囊联合rt-PA静脉溶栓对急性缺血性脑卒中患者IGF-1、MMP-9水平的影响  

Effect of Sanqi Tongshu Capsule Combined with rt-PA Intravenous Thrombolysis on IGF-1 and MMP-9 Levels in Patients with Acute Ischemic Stroke

作　　者：赵舒平 王雪玲 王文辉 ZHAO Shu-ping;WANG Xue-ling;WANG Wen-hui(Baoji Fufeng County People's Hospital,Baoji Shaanxi 722299)

机构地区：[1]宝鸡市扶风县人民医院,陕西宝鸡722299

出　　处：《医学临床研究》2023年第4期543-546,共4页Journal of Clinical Research

摘　　要：【目的】探讨三七通舒胶囊联合重组组织型纤溶酶原激活剂(rt-PA)静脉溶栓对急性缺血性脑卒中(AIS)患者胰岛素样生长因子-1(IGF-1)、基质金属蛋白酶-9(MMP-9)水平的影响。【方法】本院收治的240例AIS患者,随机分为观察组和对照组,每组120例。对照组采用rt-PA静脉溶栓治疗,观察组采用三七通舒胶囊联合rt-PA静脉溶栓治疗,均持续治疗4周。比较两组患者治疗后的疗效、不良反应及治疗前后日常生活能力Barthel指数(BI)、神经功能评分(NIHSS)、平衡功能评分(BBS)、中医症状评分及IGF-1、MMP-9、降钙素基因相关肽(CGRP)水平。【结果】治疗后,观察组患者NIHSS评分明显低于治疗前及对照组治疗后,BBS、BI评分明显高于治疗前及对照组治疗后(P<0.05);观察组患者治疗总有效率为95.00%,明显高于对照组的87.50%(P<0.05);治疗后,观察组半身不遂、口眼歪斜、言语不利各项评分均低于治疗前及对照组治疗后(P<0.05);治疗后,观察组患者血清MMP-9、CGRP水平明显低于治疗前及对照组治疗后,IGF-1水平明显高于治疗前及对照组治疗后(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。【结论】三七通舒胶囊联合rt-PA静脉溶栓治疗AIS能提高临床疗效,调节患者血清MMP-9、IGF-1、CGRP水平,改善神经功能,提高日常生活能力及平衡能力,且不增加药物不良反应。【Objective】To explore the effect of Sanqi Tongshu capsule combined with recombinant tissue plasminogen activator(rt-PA)intravenous thrombolysis on the levels of insulin-like growth factor-1(IGF-1)and matrix metalloproteinase-9(MMP-9)in patients with acute ischemic stroke(AIS).【Methods】A total of 240 patients with AIS admitted to our hospital were randomly divided into two groups,with 120 cases in each group.The control group was treated with rt-PA intravenous thrombolysis,while the observation group was treated with Sanqi Tongshu capsule combined with rt-PA intravenous thrombolysis.The treatment in the two groups lasted for 4 weeks.The curative effect,adverse reactions and the levels of Barthel index(BI),neurological function score(NIHSS),balance function score(BBS),TCM symptom score,IGF-1,MMP-9,calcitonin gene-related peptide(CGRP)of the two groups were compared before and after treatment.【Results】After treatment,the serum NIHSS of patients in the observation group was significantly lower than that before treatment in the observation group and after treatment in the control group,and the scores of BBS and BI were significantly higher than those before treatment of the observation group and after treatment in of the control group(P<0.05).The total effective rate of treatment in the observation group was 95.00%,which was significantly higher than 87.50%in the control group(P<0.05).After treatment,the scores of hemiplegia,mouth and eye deviation,and speech impairment in the observation group were lower than those before treatment in the observation group and after treatment in the control group(P<0.05).The levels of serum MMP-9 and CGRP of the observation group after treatment were significantly lower than those of the observation group before treatment and of the control group after treatment,while the level of IGF-1 was significantly higher than that of the observation group before treatment and of the control group after treatment(P<0.05).There was no statistically significant difference in the incid

关 键 词：脑缺血 卒中 急性病 组织型纤溶酶原激活物/药理学 三七通舒胶囊/药理学 

分 类 号：R743.3[医药卫生—神经病学与精神病学]