发酵纤维素阴离子衍生物的转化与抗菌应用评价  

Conversion of anionic derivatives of fermented cellulose and evaluation of their antifungal effect

作　　者：崔艳丽[1] 李顺尧 张天宇 张敏燕 鲍祥祥 毛旸易 CUI Yanli;LI Shunyao;ZHANG Tianyu;ZHANG Minyan;BAO Xiangxiang;MAO Yangyi(Department of Chemistry,Zhejiang University,Hangzhou 310058,China;Zhengzhou College of Finance and Economics,Zhengzhou 450044,China;Wuhan University,Wuhan 430072,China)

机构地区：[1]浙江大学化学系,浙江杭州310058 [2]郑州财经学院,河南郑州450044 [3]武汉大学,湖北武汉430072

出　　处：《浙江大学学报（理学版）》2023年第3期346-350,359,共6页Journal of Zhejiang University（Science Edition）

基　　金：国家重点研发计划项目(2022YFF0904100);浙江省文物保护科技项目(2020011);江苏省科技项目(XZ-SZ202027);国家重点研发计划项目(2020YFC1521800).

摘　　要：在水相条件下用阴离子醚化剂(3-氯-2-羟基丙磺酸钠)通过一锅法对经微生物改造的纤维素阴离子化,其中的氢氧化钠溶液既作为反应物、溶剂,又作为催化剂,反应条件温和、取代度适中、转化率较高。采用元素分析、核磁共振、傅里叶红外光谱等表征方法研究了纤维素衍生物的取代度和结构,结果表明,获得的纤维素产物已阴离子化。对纤维素衍生物进行了抑制真菌评估,证明其具其有一定的抑菌特性。纤维素衍生物的生态亲和性决定其可应用于文物保护、农业和防疫等领域。In this paper it is reported firstly that fermented cellulose was anionized by one pot method with sodium 3-chloro-2-hydroxypropane sulfonate in aqueous phase,and sodium hydroxide solution was used as reactant,solvent,and catalyst.The reaction conditions were mild,the degree of substitution was moderate,and the conversion rate was acceptable.The characterization of cellulose derivative was studied by means of elemental analysis,nuclear magnetic resonance,FTIR and so on.The antifungal biological evaluation of cellulose derivative was carried out,and the results showed that it had certain antifungal properties.The ecological compatibility of cellulose derivatives confirms that they can be applied in archaeology,agriculture and epidemic prevention,etc.

关 键 词：发酵纤维素 阴离子衍生物 抗菌作用 一锅法 

分 类 号：O65[理学—分析化学]