进展期食管鳞癌术后患者的生存状况及预后影响因素分析  

Analysis of Survival Status and Prognostic Factors of Patients with Advanced Esophageal Squamous Cell Carcinoma after Operation

作　　者：毕良文[1] 时前军[1] 张丽珍[1] Bi Liang-wen;Shi Qian-jun;Zhang Li-zhen(Department of Radiotherapy,the Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,Jiangsu Province,China)

机构地区：[1]南京医科大学第二附属医院放疗科,江苏南京210011

出　　处：《中外医药研究》2022年第18期36-38,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:探讨进展期食管鳞癌患者术后生存状况及预后影响因素。方法:回顾性分析2010年1月—2019年12月南京医科大学第二附属医院放疗科收治的进展期食管鳞癌术后放疗后患者109例的临床资料,利用Kaplan-Meier法进行生存率统计,进行Log-rank时序检验,利用Cox模型进行多因素分析,筛选预后影响因素。结果:109例进展期食管鳞癌患者1、3、5年生存率分别为96.3%、68.8%、28.1%。单因素分析结果显示,病变长度、不良预后因素(脉管癌栓、神经侵犯、切缘阳性)、T分期、N分期、TNM分期、肿瘤分化程度对生存期有影响(P<0.05);多因素分析显示,TNM分期是预后的独立影响因素(P<0.05)。结论:有术后不良预后因素、病变长度>3 cm,分化程度差、TNM分期为ⅢB期的患者,可能从术后辅助治疗中获益更大。Objective:To investigate the survival status and prognostic factors of patients with advanced esophageal squamous cell carcinoma.Methods:A retrospective analysis was performed on the clinical data of one hundred and nine patients with advanced esophageal squamous cell carcinoma after postoperative radiotherapy admitted to the Department of Radiotherapy,the Second Affiliated Hospital of Nanjing Medical University from January 2010 to December 2019.Kaplan-Meier method was used for survival statistics,Log-rank time series test was conducted,and Cox model was used for multivariate analysis to screen prognostic factors.Results:The 1-year,3-year and 5-year survival rates of one hundred and nine patients with advanced esophageal squamous cell carcinoma were 96.3%,68.8%and 28.1%,respectively.Univariate analysis showed that lesion length,adverse prognostic factors(vascular thrombus,nerve invasion,positive incisal margin),T stage,N stage,TNM stage,and tumor differentiation degree had influence on survival(P<0.05).Multifactor analysis showed that TNM stage was an independent prognostic factor(P<0.05).Conclusion:Patients with adverse prognostic factors,lesion length>3 cm,poor differentiation,and TNM stageⅢB may benefit more from postoperative adjuvant therapy.

关 键 词：食管鳞癌 生存状况 预后 影响因素 

分 类 号：R73[医药卫生—肿瘤]