温敏型水凝胶在区域神经阻滞中的研究进展  

Research progress of thermosensitive hydrogel in regional nerve block

作　　者：郭颖[1] 张兴裕 顾育萌 刘铁成[1] GUO Ying;ZHANG Xingyu;GU Yumeng;LIU Tiecheng(Department of Anaesthesia,The Second Hospital of Jilin University,Changchun 130041,China)

机构地区：[1]吉林大学第二医院麻醉科,长春130041

出　　处：《长春中医药大学学报》2023年第5期586-590,共5页Journal of Changchun University of Chinese Medicine

基　　金：吉林省教育厅“十三五”科学技术项目(JJKH2019005KJ)。

摘　　要：随着医疗水平的提高以及外科技术的进步,很多普通外科、骨科和妇科手术往往会选择区域神经阻滞技术来提高患者的麻醉质量。区域神经阻滞具有减少其他镇痛药物(阿片类)剂量;降低术后恶心呕吐(PONV)的发生率;保留患者意识和保护性反射;提供更完善的术后镇痛效果;费用低廉等突出优点。然而,临床上行区域神经阻滞镇痛时单次注射局部麻醉药镇痛时间受限,远远不能满足术后镇痛需求。因此,麻醉医生一直在进行不断研究解决阻滞持续时间的方法,如加入佐剂更换麻醉药物、使用周围神经导管进行持续注射等。温敏型水凝胶的出现为解决这一问题提供了新的思路。With the improvement of medical standards and the advancement of surgical techniques,some patients in general surgery,orthopedics and gynecological surgery often choose regional nerve block technology to improve the quality of anesthesia.Regional nerve blocks have the outstanding advantages such as reducing the dose of other analgesic drugs(opioids),reducing the incidence of postoperative nausea and vomiting(PONV),preserving the awareness and protective refl exes of patient,providing improved postoperative analgesic eff ects and lower cost and so on.However,in clinical practice,during ascending regional nerve block analgesia,the time for single injection of local anesthetics is limited and far from meeting the postoperative analgesia needs.Therefore,anesthesiologists have been studying ways to solve the problem of block duration,such as adding adjuvants,changing anesthetic drugs,and using peripheral nerve catheters for continuous injection and so on.The emergence of thermosensitive hydrogels provides a new way to solve this problem.

关 键 词：控制释放 区域神经阻滞 热凝胶 镇痛 

分 类 号：R614.4[医药卫生—麻醉学]