空腹血糖水平和胆石病患病风险的关联分析  

The association between fasting blood glucose levels and risk of gallstones: a national multicenter study

作　　者：朱培 单雪峰[3] 崔平 李光灿 张弛 于文倩 何明升 江果恒 李鸿钰 李诗懿 张本 王新 ZHU Pei;SHAN Xue-feng;CUI Ping;LI Guang-can;ZHANG Chi;YU Wen-qian;HE Ming-sheng;JIANG Guo-heng;LI Hong-yu;LI Shi-yi;ZHANG Ben;WANG Xin(Department of Epidemiology and Health Statistics,West China School of Public health/West China Fourth Hospital,Sichuan University,Chengdu,Sichuan 610041,China;不详)

机构地区：[1]四川大学华西公共卫生学院/华西第四医院流行病学与卫生统计学系,四川成都610041 [2]四川大学华西公共卫生学院/华西第四医院陈志潜研究院,四川成都610041 [3]重庆医科大学第一附属医院药剂科 [4]济宁医学院公共卫生学院 [5]开州区人民医院药剂科 [6]天津医科大学肿瘤医院 [7]四川大学华西公共卫生学院/华西第四医院劳动卫生与环境卫生学系

出　　处：《现代预防医学》2023年第8期1350-1355,共6页Modern Preventive Medicine

基　　金：国家自然科学基金(81673255,81874283,81903398);中国青年专业人员招聘计划;四川大学基础医学推广计划和尖端学科发展计划;陆军军医大学项目(WX2015-013,2018XLC1004,SWH2018BJJJ-12);陆军军医大学第一附属医院项目(S2016ZDCX1012);中央高校基本科研基金(YJ2021112);四川省医学会医学科研青年创新课题(Q21016);四川省杰出青年科学基金(2023NSFSC1927);四川天府峨眉计划青年人才项目(川峨眉第184号)。

摘　　要：目的评估人群空腹血糖水平与胆结石患病风险之间的关联性。方法本研究纳入天津医科大学肿瘤医院、济宁市人民医院、重庆市开州区人民医院、重庆黔江中心医院和重庆医科大学附属第一医院5家单位2015—2020年期间参加健康体检的研究对象。在各研究中心中使用多变量logistic回归分析评估空腹血糖和胆结石患病风险之间的关联性,再用meta分析的方法对各个中心的研究结果进行合并。结果本研究共纳入585071名研究对象,其中41852人被诊断为胆结石。与<6.10 mmol/L血糖水平相比,空腹血糖≥6.10 mmol/L和≥7.0 mmol/L人群胆结石患病风险为1.82(95%CI:1.50~2.22)和2.61(95%CI:2.21~3.10)。空腹血糖每上升1 mmol/L和1个标准差胆结石患病风险为1.05(95%CI:1.04~1.07)和1.06(95%CI:1.04~1.09)。经年龄和性别分组后,空腹血糖和胆结石的关联性未受显著影响。结论较高的血糖水平可能增加胆结石发病风险,该结果可能对胆结石发病机制探讨和高危人群识别提供基础。Objective To evaluate the association between fasting blood glucose levels and the risk of gallstones through a large national multi-center study.Methods The subjects who participated in physical examination during 2015-2020 were included in this study from 5 institutions:Tianjin Medical University Cancer Hospital,Jining People's Hospital,Chongqing Kaizhou District People's Hospital,Chongqing Qianjiang Central Hospital and the First Affiliated Hospital of Chongqing Medical University.Firstly,multivariate logistic regression analysis was used to evaluate the association between fasting blood glucose and gallstone risk in each study center,and then meta-analysis was used to combine the results of the studies in each study center.Results A total of 585071 subjects were included in this study,among which 41852 were diagnosed with gallstones.Compared with the blood glucose level of<6.10 mmol/L,the risk of gallstones in people with a fasting blood glucose of≥6.10 mmol/L and≥7.0 mmol/L is 1.82(95%CI:1.50-2.22)and 2.61(95%CI:2.21-3.10).The risk of gallstones is 1.05(95%CI:1.04-1.07)and 1.06(95%CI:1.04-1.09)for each increase of fasting blood glucose by 1 mmol/L and 1 standard deviation.The association between fasting blood glucose and gallstones was not significantly affected by age and sex groups.Conclusion High blood glucose levels may increase the risk of gallstones,which may provide a basis for the pathogenesis of gallstones and the identification of high-risk groups.

关 键 词：空腹血糖 胆结石 多中心 横断面研究 

分 类 号：R575.62[医药卫生—消化系统]