基于闭环控制的经颅超声刺激调节运动响应和神经活动  

Modulation of motor responses and neural activities with transcranial ultrasound stimulation based on closed-loop control

作　　者：董舒寻 谢振宇 王星冉 袁毅[1] DONG Shuxun;XIE Zhenyu;WANG Xingran;YUAN Yi(School of Electrical Engineering,Yanshan University,Qinhuangdao,Hebei 066004,P.R.China)

机构地区：[1]燕山大学电气工程学院,河北秦皇岛066004

出　　处：《生物医学工程学杂志》2023年第2期265-271,共7页Journal of Biomedical Engineering

基　　金：国家自然科学基金项目(61827811)。

摘　　要：闭环经颅超声刺激技术基于实时反馈信号,具备对神经活动进行精准调控的潜力。在本文中,首先记录了不同强度的超声刺激下小鼠的局部场电位(LFP)和肌电(EMG)信号,然后基于数据离线建立了超声强度与小鼠LFP峰值/EMG均值的数学模型,仿真并搭建了PID神经网络控制算法调节小鼠LFP峰值和EMG均值的经颅超声闭环控制系统,实现了小鼠LFP峰值和EMG均值闭环控制。另外,使用广义最小方差控制算法,实现了对小鼠theta振荡功率的闭环控制。结果显示,闭环超声刺激调控后的LFP峰值、EMG均值和theta功率与给定值未见明显差异,说明实现了对小鼠LFP峰值、EMG均值和theta功率明显的控制作用。基于闭环控制算法的经颅超声刺激提供了一种精准调节小鼠电生理信号的直接工具。Closed-loop transcranial ultrasound stimulation technology is based on real-time feedback signals, and has the potential for precise regulation of neural activity. In this paper, firstly the local field potential(LFP) and electromyogram(EMG) signals of mice under different intensities of ultrasound stimulation were recorded, then the mathematical model of ultrasound intensity and mouse LFP peak/EMG mean was established offline based on the data,and the closed-loop control system of LFP peak and EMG mean based on PID neural network control algorithm was simulated and built to realize closed-loop control of LFP peak and EMG mean of mice. In addition, using the generalized minimum variance control algorithm, the closed-loop control of theta oscillation power was realized. There was no significant difference between the LFP peak, EMG mean and theta power under closed-loop ultrasound control and the given value, indicating a significant control effect on the LFP peak, EMG mean and theta power of mice. Transcranial ultrasound stimulation based on closed-loop control algorithms provides a direct tool for precise modulation of electrophysiological signals in mice.

关 键 词：经颅超声刺激 闭环控制 PID神经网络控制 广义最小方差控制 

分 类 号：TP273[自动化与计算机技术—检测技术与自动化装置] R445.1[自动化与计算机技术—控制科学与工程]