血管紧张素转换酶2在非小细胞肺癌与SARSCoV-2中共表达的研究进展  

Research progress of angiotensin converting enzyme 2 co-expression in non-small cell lung cancer and SARS-CoV-2

作　　者：白向豆 曾伟强 崔百强 王兵 杨宁 贺晓阳 张斯渊 金大成 苟云久 BAI Xiangdou;ZENG Weiqiang;CUI Baiqiang;WANG Bing;YANG Ning;HE Xiaoyang;ZHANG Siyuan;JIN Dacheng;GOU Yunjiu(The First Clinical Medical College of Gansu University of Chinese Medicine,Lanzhou,730000,P.R.China;Department of Thoracic Surgery,The Gansu Provincial Hospital,Lanzhou,730000,P.R.China)

机构地区：[1]甘肃中医药大学第一临床医学院,兰州730000 [2]甘肃省人民医院胸外一科,兰州730000

出　　处：《中国胸心血管外科临床杂志》2023年第5期773-778,共6页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

摘　　要：自2019年底首例由严重急性呼吸综合征冠状病毒2(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)引起的新型冠状病毒感染(corona virus disease 2019,COVID-19)出现以来,该病毒在全球范围内迅速传播,已成为全球公共卫生问题。在此次病毒流行过程中,相比于普通人群,癌症患者被认为是高度易感人群,尤其是肺癌患者。有部分研究表明血管紧张素转换酶2(angiotensin converting enzyme,ACE2)可能是SARSCoV-2感染宿主的途径。同时,ACE2常在非小细胞肺癌中呈现出异常表达。因此了解ACE2在COVID-19与非小细胞肺癌中各自的作用机制,对于研究疫苗以及治疗性药物具有极其重要的参考价值,同时也为疫情期间肺癌患者的防护提出有意义的指导意见。本文综述了ACE2在SARS-CoV-2中可能的侵袭机制,以及其在非小细胞肺癌中异常表达的研究进展。Since the first case of corona virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)at the end of 2019,the virus has spread rapidly around the world and has become a global public health problem.In the process of this virus epidemic,compared with the general population,cancer patients are considered to be highly susceptible people,especially the lung cancer patients.Some studies have shown that angiotensin converting enzyme 2(ACE2)may be the pathway for SARS-CoV-2 to infect the host.At the same time,ACE2 is often abnormally expressed in non-small cell lung cancer.Therefore,understanding the respective mechanisms of ACE2 in COVID-19 and non-small cell lung cancer has extremely important reference value for the study of vaccines and therapeutic drugs,and also provides meaningful guidance for the protection of patients with lung cancer during the epidemic.This article reviews the possible invasive mechanism of ACE2 in SARS-CoV-2 and its abnormal expression in non-small cell lung cancer.

关 键 词：非小细胞肺癌 血管紧张素转换酶2(ACE2) 严重急性呼吸综合征冠状病毒2(SARS-CoV-2) SPIKE蛋白 新型冠状病毒感染(COVID-19) 综述 

分 类 号：R734.2[医药卫生—肿瘤]