Chiral phenethylamine synergistic tricarboxylic acid modified β-cyclodextrin immobilized on porous silica for enantioseparation  

作　　者：Hui Li Xiaoping Wang Chengxiang Shi Liang Zhao Zuguang Li Hongdeng Qiu 

机构地区：[1]CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province,Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences,Lanzhou 730000,China [2]College of Chemical Engineering,Zhejiang University of Technology,Hangzhou 310014,China

出　　处：《Chinese Chemical Letters》2023年第3期162-165,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.22074154 and 22174129);Nature Science Foundation of Zhejiang Province(No.LZY21E030001);Foundation for Science and Tech Research Project of Gansu Province(Nos.20JR10RA052 and 20JR10RA292);LICP Cooperation Foundation for Young Scholars(No.HZJJ20-08)。

摘　　要：In this work, a series of chiral phenethylamine synergistic tricarboxylic acid modified β-cyclodextrin bonded stationary phase for high performance liquid chromatography(HPLC) were synthesized via a simple one-pot synthesis approach. Various racemates(aryl alcohols, flavanones, triazoles, benzoin, etc.) were well separated on the tricarboxylic acid modified chiral stationary phases in both normal and reversed modes with good reproducibility and stability, and the influence of mobile phase composition on resolution(R_(s)) were deeply investigated. The RSD values of Rsfor repeatability and column-to-column were below 1.28% and 3.05%, respectively. Hence, the fabrication of tricarboxylic acid modified chiral stationary phase(CSPs) is a new efficient strategy to improve the application of β-cyclodextrin as CSPs in the field of chromatography.

关 键 词：Tricarboxylic acid Β-CYCLODEXTRIN Chiral stationary phases ENANTIOSEPARATION One-pot strategy 

分 类 号：TQ450.1[化学工程—农药化工] O657.72[理学—分析化学]