视神经脊髓炎谱系疾病复发危险因素的研究进展  

Research progress on risk factors of recurrence of neuromyelitis optica spectrum disorders

作　　者：代淑华 滕勇士 蒋玙姝 秦灵芝[2] 薛红飞 徐佳佳 李玮[2] DAI Shuhua;TENG Yongshi;JIANG Yushu;QIN Lingzhi;XUE Hongfei;XU Jiajia;LI Wei(Xinxiang Medical University,Xinxiang,Henan,453003;Department of Neurology,Henan Provincial People′s Hospital,Zhengzhou,Henan,450003;Zhengzhou University,Zhengzhou,Henan,450000;Henan University,Zhengzhou,Henan,450046)

机构地区：[1]新乡医学院,河南新乡453003 [2]河南省人民医院神经内科,河南郑州450003 [3]郑州大学,河南郑州450000 [4]河南大学,河南郑州450046

出　　处：《实用临床医药杂志》2023年第8期126-129,134,共5页Journal of Clinical Medicine in Practice

基　　金：河南省医学科技攻关计划项目(SBGJ2018077)。

摘　　要：视神经脊髓炎谱系疾病(NMOSD)是一种罕见的、高复发性、高致残性的原发性中枢神经系统炎性脱髓鞘性疾病。患者的神经功能障碍反复发作,症状逐渐累积,最终造成不可挽救的临床结局。因此,预防复发成为NMOSD治疗中的关键,阐明其复发的特点和病理机制也迫在眉睫。然而,目前对影响NMOSD患者复发频率、严重程度、复发形式的潜在因素知之甚少。本文对NMOSD复发相关因素的研究进展进行综述,以期为NMOSD复发评估提供一定参考。Neuromyelitis optica spectrum disorders(NMOSD)is a rare,highly recurrent and disabling primary inflammatory demyelinating disease of central nervous system.Recurrent neurological dysfunction in patients can gradually promote the accumulation of symptoms,and ultimately resulting in irreparable clinical outcomes.Therefore,prevention of recurrence has become a key factor in the treatment of NMOSD,and it is urgent to elucidate the characteristics and pathological mechanisms of recurrence.However,it is currently rarely known about the potential factors that affect the frequency,severity and form of recurrence in NMOSD patients.In this paper,the research progress on recurrence-related factors of NMOSD was reviewed in order to provide reference for recurrence assessment of NMOSD.

关 键 词：视神经脊髓炎谱系疾病 人口统计学特征 水通道蛋白4 自身免疫性疾病 脊髓星形胶质细胞 细胞因子 水通道蛋白4抗体 

分 类 号：R744.5[医药卫生—神经病学与精神病学] R744.3[医药卫生—临床医学]