养正消积胶囊辅助化疗方案对非小细胞肺癌患者的治疗效果分析  

Analysis of the Therapeutic Effect of Adjuvant Chemotherapy Regimen of Nourishing and Eliminating Capsules on Patients with Non-small Cell Lung Cancer

作　　者：毛跃峰 MAO Yue-feng(Pingdingshan Second People’s Hospital,Pingdingshan,Henan,467300,China)

机构地区：[1]平顶山市第二人民医院,河南平顶山4673000

出　　处：《黑龙江医学》2023年第10期1195-1197,共3页Heilongjiang Medical Journal

摘　　要：目的:分析养正消积胶囊辅助化疗方案对非小细胞肺癌(NSCLC)患者的治疗效果。方法:回顾性分析2020年10月-2021年6月平顶山市第二人民医院收治的96例NSCLC患者的临床资料,采用随机数表法分为对照组与观察组,每组各48例。对照组接受常规化疗,观察组在常规治疗的基础上接受养正消积胶囊辅助化疗,两组患者均治疗3个月。比较两组患者治疗前后的中医证候评分、日常生活能力评定量表(ADL)评分、疾病控制率及不良反应发生情况。结果:两组患者均完成3个月的治疗,无中途退出与失访病例,有效率为100.00%。观察组的DCR为91.67%,高于对照组的64.58%,差异有统计学意义(χ^(2)=10.301,P<0.05)。治疗后,两组患者证候评分均低于治疗前,且观察组汗出气短评分为(1.83±0.19)分、心胸胀痛评分为(2.04±0.24)分、气促胸闷评分为(1.95±0.21)分,低于对照组的(2.20±0.22)分、(2.52±0.26)分、(2.35±0.24)分,差异有统计学意义(t=8.539、9.100、8.414,P<0.05)。治疗后,两组患者进阶能力评分、基本能力评分均高于治疗前,且观察组进阶能力评分为(36.63±1.92)分、基本能力评分为(57.34±1.12)分,高于对照组的(32.21±2.56)分、(53.86±2.35)分,差异有统计学意义(t=10.731、10.370,P<0.05)。观察组肝功能损害、血细胞减少、骨髓抑制等不良反应的总发生率为14.58%,低于对照组的33.33%,差异有统计学意义(χ^(2)=4.631,P<0.05)。结论:养正消积胶囊辅助化疗方案应用于NSCLC癌患者中,可有效提高患者疾病控制率,改善患者生活质量,降低其中医证候评分及化疗不良反应发生率。Objective:To analyze the efficacy of adjuvant chemotherapy regimen of Yangzheng and Xiezhi capsules in patients with non-small cell lung cancer(NSCLC).Methods:The clinical data of 96 patients with NSCLC admitted to the hospital from October 2020 to June 2021 were retrospectively analyzed,and the random number table method was used to divide them into a control group and an observation group,with 48 cases in each group.The control group received conventional chemotherapy and the observation group received adjuvant chemotherapy based on conventional treatment with Yangzheng and Cure Capsules,and patients in both groups were treated for 3 months.The patients in both groups were treated for 3 months.The TCM symptoms scores,ADL scores,disease control rate and the occurrence of adverse reactions were compared before and after treatment.Results:Patients in both groups completed 3 months of treatment,with no cases of withdrawal and missed visits,and the effective rate was 100.00%.The DCR of the observation group was 91.67%,which was higher than 64.58%of the control group,and the difference was statistically significant(χ^(2)=10.301,P<0.05).After treatment,the evidence scores of patients in both groups were lower than those before treatment.The score of sweating and shortness of breath in the observation group was(1.83±0.19)points,the score of cardiothoracic distension was(2.04±0.24)points,and the score of shortness of breath and chest tightness was(1.95±0.21)points,which were lower than the scores of(2.20±0.22)points,(2.52±0.26)points,and(2.35±0.24)points in the control group,and the differences were statistically significant(t=8.539,9.100,8.414,P<0.05).After treatment,the progressive ability scores and basic ability scores were higher in both groups than before treatment.The progressive ability score and basic ability score of the observation group were(36.63±1.92)points and(57.34±1.12)points,which were higher than those of the control group(32.21±2.56)points and(53.86±2.35)points,with statistically significa

关 键 词：非小细胞肺癌 养正消积胶囊 生活质量 中医证候评分 

分 类 号：R734.2[医药卫生—肿瘤]