Toll样受体5基因rs2072493与肝癌易感性的关系  

Relationship between SNP rs2072493 in TLR5 and susceptibility to primary liver cancer

作　　者：秦金东[1] 高芳[1] 李迎泽 李鹏 贾彦彬[1] QIN Jindong;GAO Fang;LI Yingze;LI Peng;JIA Yanbin(Baotou Medical College,Baotou 014040,China;Baotou Tumor Hospital;Ordos Second People’s Hospital)

机构地区：[1]包头医学院,内蒙古包头014040 [2]包头市肿瘤医院 [3]鄂尔多斯市第二人民医院

出　　处：《包头医学院学报》2023年第5期6-9,共4页Journal of Baotou Medical College

基　　金：内蒙古自然科学基金(2019LH08045);包头医学院创新团队项目(bycxtd-06);内蒙古自治区卫生健康科技计划项目(202201392)。

摘　　要：目的:探讨Toll样受体5基因单核苷酸多态性(single nucleotide polymorphism SNP)rs2072493位点与肝癌遗传易感性的关系。方法:采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)法检测205例肝癌病例组和238例正常对照组Toll样受体5基因SNP rs2072493的基因型分布。用非条件性Logistic回归计算比值比(OR)及其95%置信区间评估在共显性、显性、隐性、超显性四种遗传模式下rs2072493与肝癌发病风险的关系。结果:在共显性、显性、隐性遗传模式下,Toll样受体5基因SNP rs2072493与肝癌的发病风险有关联。其中共显性遗传模式最适合,AIC和BIC最小。与携带AA基因型者相比,携带GA和GG基因型者肝癌的发病风险降低(GA vs AA:OR=0.512,95%CI=0.333-0.787、GG vs AA:OR=0.192,95%CI=0.077-0.477)。结论:Toll样受体5基因SNP rs2072493与肝癌发病风险关联。Objective:To investigate the relationship between SNP rs2072493 in Toll-like receptor 5(TLR5)gene and genetic susceptibility to primary liver cancer.Methods:Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)method was used to detect the genotype distributions of SNP rs2072493 in 205 patients with primary liver cancer and 238 normal people.The odds ratio(OR)and 95%confidence interval(CI)were calculated by non-conditional logistic regression to evaluate the relationship between rs2072493 and the risk of primary liver cancer under the four genetic models of Codominant,Dominant,Recessive and Overdominant.Results:SNP rs2072493 was associated with the risk of primary liver cancer under Codominant,Dominant and Recessive genetic models.The codominant genetic model was the best model with the lowest AIC and BIC value.Compared with AA genotype,GA and GG genotype could reduce the risk of primary liver cancer(GA vs AA:OR=0.512,95%CI=0.333-0.787;GG vs AA:OR=0.192,95%CI=0.077-0.477).Conclusion:SNP rs2072493 in TLR5 is associated with the risk of primary liver cancer.

关 键 词：TOLL样受体5 基因 原发性肝癌 关联 

分 类 号：R735.7[医药卫生—肿瘤]