高度近视眼白内障术后后囊膜混浊的炎性反应机制  

Mechanism of inflammatory response in posterior capsule opacification after cataract surgery in high myopia

作　　者：马慧[1] 鲍永珍[1] Ma Hui;Bao Yongzhen(Department of Ophthalmology,Peking University People’s Hospital,Eye Diseases and Optometry Institute,Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases,College of Optometry,Peking University Health Science Center,Beijing 100044,China)

机构地区：[1]北京大学人民医院眼科,视觉损伤与修复教育部重点实验室,视网膜脉络膜疾病诊治研究北京市重点实验室,100044

出　　处：《国际眼科纵览》2023年第2期121-125,共5页International Review of Ophthalmology

基　　金：豪雅(深圳)医疗器械咨询有限公司临床跟踪研究(2119000332)。

摘　　要：高度近视是导致白内障及白内障术后后囊膜混浊(posterior capsule opacification,PCO)的高危因素。高度近视眼中PCO的发生时间更早、程度更重、治疗风险更高。炎性反应在高度近视和PCO的发病机制中起重要作用,高度近视眼中的炎性微环境与PCO的发生密切相关。高度近视眼中炎性因子如白介素-6、肿瘤坏死因子-α、转化生长因子-β及基质金属蛋白酶-2水平升高,参与了上皮间充质转化以及细胞外基质收缩,促进了PCO的发生发展。High myopia is a high risk factor for cataract and posterior capsule opacification(PCO)after cataract surgery.The occurrence time of PCO in high myopia is earlier,the degree is heavier,the treatment risk is higher.Previous studies have shown that inflammatory response plays an important role in the pathogenesis of high myopia and PCO,and the inflammatory microenvironment in high myopia seems to be closely related to the occurrence of PCO.The elevated levels of inflammatory factors such as interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),transforming growth factor-β(TGF-β),and matrix metalloproteinase-2(MMP-2)in highly myopic eyes are involved in epithelial-mesenchymal transition and extracellular matrix contraction,which promotes the development of PCO.

关 键 词：高度近视 后囊膜混浊 炎性反应 

分 类 号：R779.66[医药卫生—眼科] R778.11[医药卫生—临床医学]