CT能谱成像结合AFP、GP73及GPC-3检测对小肝癌的诊断价值  

Diagnostic value of CT spectral imaging combined with detection of AFP,GP73 and GPC-3 in small hepatocellular carcinoma

作　　者：郭大鹏 龙仲云 胡海菁 GUO Dapeng;LONG Zhongyun;HU Haijing(Department of Radiology,the Sixth Affiliated Hospital of South China University of Technology,Foshan,Guangdong,China,528200)

机构地区：[1]华南理工大学附属第六医院放射科,广东佛山528200

出　　处：《分子诊断与治疗杂志》2023年第4期581-584,共4页Journal of Molecular Diagnostics and Therapy

基　　金：佛山市科技创新项目(自筹经费类科技计划项目)(2020001004873)。

摘　　要：目的 探究CT能谱成像结合甲胎蛋白(AFP)、高尔基体蛋白73(GP73)、磷脂酰基醇蛋白聚糖3(GPC-3)检测对小肝癌(SHCC)的诊断价值。方法 选择华南理工大学附属第六医院2021年2月至2022年7月间收治的105例小肝癌患者作为SHCC组,另选94例肝脏良性疾病患者作为肝脏良性疾病组,82名健康体检志愿者作为对照组,对比三组AFP、GP73、GPC-3水平以及阳性表达率,并分析CT能谱成像、AFP、GP73、GPC-3检测对SHCC的诊断结果。结果 三组AFP、GP73、GPC-3水平:对照组<肝脏良性疾病组<SHCC组,差异有统计学意义(P<0.05);三组AFP、GP73、GPC-3阳性表达率:对照组<肝脏良性疾病组<SHCC组,差异有统计学意义(P<0.05);CT能谱成像结合AFP、GP73、GPC-3检测对SHCC的诊断灵敏度(94.53%)、特异度(96.38%)、准确度(93.26%)明显高于各单项检测及AFP+GP73+GPC-3联合检测。结论 CT能谱成像结合AFP、GP73及GPC-3检测对SHCC的诊断价值较高,值得临床推广。Objective To explore the diagnostic value of CT spectral imaging combined with the detection of alpha-fetoprotein(AFP),Golgi protein 73(GP73),and glypican 3(GPC-3)in small hepatocellular carcinoma(SHCC).Methods 105 patients with small liver cancer admitted to the Sixth Affiliated Hospital of South China University of Technology from February 2021 to July 2022 were selected as the SHCC group,another 94 patients with benign liver diseases were selected as the benign liver disease group,and 82 healthy volunteers were selected as the control group,the levels of AFP,GP73,and GPC-3 and positive expression rates were compared among the three groups,and the diagnostic results of CT spectral imaging,AFP,GP73,and GPC-3 detection for SHCC were analyzed.Results The levels of AFP,GP73,and GPC-3 in the three groups:control group<benign liver disease group<SHCC group,the difference was statistically significant(P<0.05).The positive expression rates of AFP,GP73,and GPC-3 in the three groups:control group<benign liver disease group<SHCC group,the difference was statistically significant(P<0.05).The diagnostic sensitivity(94.53%),specificity(96.38%)and accuracy(93.26%)of CT energy spectrum imaging combined with AFP,GP73 and GPC-3 detection for SHCC were significantly higher than those of the single detection and AFP+GP73+GPC-3 combined detection.Conclusion CT energy spectrum imaging combined with AFP,GP73 and GPC-3 detection has a high diagnostic value for SHCC and is worthy of clinical promotion.

关 键 词：CT能谱成像 AFP GP73 GPC-3 小肝癌 

分 类 号：R735.7[医药卫生—肿瘤] R730.44[医药卫生—临床医学]