血清AQP-1、AQP-4、AQP-9与急性脑梗死神经功能康复的相关性  

Correlation between serum AQP-1,AQP-4,and AQP-9 and neurological functional rehabilitation from acute cerebral infarction

作　　者：李志银 郗海涛[1] 闫旭玲 孟丽霞 LI Zhiyin;XI Haitao;YAN Xuling;MENG Lixia(Beijing Rehabilitation Hospital Affiliated to Capital Medical University Community Rehabilitation Department Beijing,China 100144)

机构地区：[1]首都医科大学附属北京康复医院,北京100144

出　　处：《分子诊断与治疗杂志》2023年第4期708-711,共4页Journal of Molecular Diagnostics and Therapy

基　　金：首都医科大学附属北京康复医院内课题(2021-068)。

摘　　要：目的研究血清(AQP)-1、AQP-4、AQP-9与急性脑梗死(ACI)神经功能康复的相关性。方法选择2019年2月至2021年11月期间首都医科大学附属北京康复医院收治的170例ACI患者为研究的ACI组,另取110名健康体检者作为对照组,检测ACI组治疗前及治疗后1月、对照组体检时的血清AQP-1、-4、-9含量,评价ACI患者的神经功能损伤程度并分为轻度损伤亚组、中度损伤亚组、重度损伤亚组,评价ACI患者的90d预后并分为预后良好亚组、预后不良亚组。采用受试者工作特征曲线(ROC)分析血清指标预测ACI预后的价值,采用logistic回归分析ACI预后不良的危险因素。结果ACI组患者治疗前的血清AQP-1、AQP-4、AQP-9含量高于对照组,差异有统计学意义(t=15.059、15.897、25.201,P<0.05);ACI组中入院时的血清AQP-1、-4、-9含量为重度损伤亚组>中度损伤亚组>轻度损伤亚组(P<0.05);预后不良亚组患者治疗后1月时的血清AQP-1、-4、-9含量高于预后良好亚组(t=5.776、4.598、7.257,P<0.05);ROC分析显示血清AQP-1、-4、-9含量单独及联合均对ACI患者预后具有预测价值;logistics回归分析显示AQP-1、-4、-9含量均是ACI患者预后不良的危险因素(P<0.05)。结论ACI患者血清AQP-1、-4、-9含量升高,在评估预后中具有预测价值。Objective To study the correlation of aquaporin(AQP)-1,-4 and-9 with neurological rehabilitation of acute cerebral infarction(ACI).Methods 170 ACI patients admitted to Beijing Rehabilitation Hospital of Capital Medical University during the 2019.2-2021.11 were selected as the ACI group,and the other 110 healthy check-up persons were taken as the control group.The contents of AQP-1,-4 and-9 in serum of ACI patients before treatment and 1 month after treatment,control group during the physical examination were detected.The degree of neurological impairment in ACI patients was evaluated and divided into the mild,moderate and severe injury subgroups,and the 90d prognosis of ACI patients was evaluated and divided into the good prognosis and the poor prognosis subgroups.The ROC analysis was used to predictive value of serum indicators on ACI prognosis,and logistic regression was used to analyze the risk factors for poor prognosis of ACI.Results The serum content of AQP-1,-4 and-9 in the ACI group before treatment was higher than that in the control group(t=15.059,15.897,25.201,P<0.05).The serum content of AQP-1,-4 and-9 at admission in the ACI group:severe injury subgroup>moderate injury subgroup>mild injury subgroup(P<0.05).The serum content of AQP-1,-4 and-9 at 1 month after treatment in the poor prognosis subgroup was higher than that in the good prognosis subgroup(t=5.776,4.598,7.257,P<0.05).The ROC analysis showed that the serum content of AQP-1,-4 and-9 alone and in combination had predictive value for the prognosis of ACI patients.Logistics regression analysis showed that the content of AQP-1,-4 and-9 were all risk factors for poor prognosis of ACI patients(P<0.05).Conclusion Serum AQP-1,-4,and-9 levels in patients with ACI are elevated,which has predictive value in evaluating prognosis.

关 键 词：急性脑梗死 水通道蛋白 预后 预测价值 

分 类 号：R743.33[医药卫生—神经病学与精神病学]