围绝经期抑郁症的研究进展  

Research progress of perimenopausal depression

作　　者：杨艳青 赵伟田 李灿委 尹爱武 范孟然 杨自忠 高鹏飞 YANG Yanqing;ZHAO Weitian;LI Canwei;YIN Aiwu;FAN Mengran;YANG Zizhong;GAO Pengfei(College of Pharmacy,Dali University,Dali 671000,China;Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D,Dali University,Dali 671000;Engineering Research Center of Exploitation and Comprehensive Utilization of Medicinal Insect Resources,Education Department of Yunnan Province,Dali 671000;Dali Prefectural Hospital of Traditional Chinese Medicine,Dali 671099;College of Public Health,Dali University,Dali 671000;Xiangtan Medicine and Health Vocational College,Xiangtan 411104)

机构地区：[1]大理大学药学院,云南大理671000 [2]云南省昆虫生物医药研发重点实验室,云南大理671000 [3]药用昆虫资源开发与综合利用云南省教育厅工程研究中心,云南大理671000 [4]大理州中医医院,云南大理671099 [5]大理大学公共卫生学院,云南大理671000 [6]湘潭医卫职业技术学院,湖南湘潭411104

出　　处：《中国比较医学杂志》2023年第5期85-92,共8页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金资助项目(81260676,82160798,81960712);中国国家留学基金(201708535007);云南省重大科技专项计划—生物资源数字化开发应用(202002AA100007)。

摘　　要：围绝经期抑郁症(perimenopausal depression,PMD)是发生在围绝经期,以情感抑郁、焦虑不安、思维迟缓等为典型临床表现的一种精神疾病。PMD发病机制主要包括激素水平、神经递质、炎症反应、脑源性神经营养因子(BDNF)等。研究表明中医药干预对于PMD具有一定的疗效。本文通过对其发病机制进行综述,以期为PMD机制研究以及治疗提供理论依据。Perimenopausal depression(PMD)is a kind of mental disease that occurs during the perimenopausal period accompanied with typical clinical manifestations of emotional depression,anxiety,and thinking retardation.The pathogenesis of PMD mainly includes hormone levels,neurotransmitters,inflammatory reactions,and brain⁃derived neurotrophic factor.It has been suggested that Traditional Chinese medicine affects PMD.In this review,the pathogenesis of PMD is discussed in order to provide a reference for mechanistic research and treatment of PMD.

关 键 词：围绝经期抑郁 机制 激素 神经递质 炎症反应 脑源性神经营养因子 

分 类 号：R-33[医药卫生]