基于文献数据库的药物诱导的抑郁动物模型的研究进展  

Literature review of animal models of depression induced by drugs

作　　者：陈俣祯 姜宁 裴海月 陈芳 袁志鹰[3,4] 谢梦洲 CHEN Yuzhen;JIANG Ning;PEI Haiyue;CHEN Fang;YUAN Zhiying;XIE Mengzhou(Hunan Engineering Technology Research Center for Medicinal and Functional Food,Changsha 410208,China;Institute of Medicinal Plant Development Chinese Academy of Medical Science and Peking Union Medical Medical College,Bejing 100193;Key Laboratory of TCM Heart and Lung Syndrome Differentiation&Medicated Diet and Dietotherapy,Hunan University of Chinese Medicine,Changsha 410208;Provincial Key Laboratory of TCM Diagnostics,Hunan University of Chinese Medicine,Changsha 410208;Hunan University of Chinese Medicine,Changsha 410208;Institute of Food Science and Technology,Chinese Academy of Agricultural Sciences,Key Laboratory of Agro-Products Processing,Ministry of Agriculture and Rural Affairs,Beijing 100193)

机构地区：[1]湖南省药食同源功能性食品工程技术研究中心,长沙410208 [2]中国医学科学院北京协和医学院药用植物研究所,北京100193 [3]湖南中医药大学中医心肺病证辨证与药膳食疗重点研究室,长沙410208 [4]湖南中医药大学中医诊断学湖南省重点实验室,长沙410208 [5]湖南中医药大学,长沙410208 [6]中国农业科学院农产品加工研究所,农业农村部农产品加工质量安全风险评估实验室,农业农村部农产品质量安全收贮运管控重点实验室,北京100193

出　　处：《中国比较医学杂志》2023年第5期134-144,共11页Chinese Journal of Comparative Medicine

基　　金：湖南省重点研发计划(2022SK2018);研究生创新创业项目(2022CX46);“一方”研究生创新项目(2021YF01)。

摘　　要：抑郁症是一种严重危害人类身心健康的疾病,建立良好的抑郁症动物模型对其发病机制的研究及抗抑郁药物研发具有重要的意义。在抑郁症动物模型中,药物诱导抑郁动物模型因操作简便、节省时间等优点而被广泛使用。本文通过系统查阅中国知网(CNKI)和PubMed两大数据库,对自建库起至2021年7月1日以来关于药物诱导的抑郁症动物模型的文献进行分析整理,综述了六种常用的药物诱导抑郁动物模型的使用频次、造模动物选择、药物注射剂量和注射方式、模型的评价指标以及优缺点等方面,以期为抑郁症动物模型的制备及相应的药物研发提供参考。Depression is a disease that seriously endangers human physical and mental health.The establishment of a suitable animal model of depression is of great significance to study its pathogenesis and develop drugs.Among the animal models of depression,animal models of drug⁃induced depression are widely used because of the advantages of simplicity and timely establishment.This article systematically reviewed drug⁃induced depression animal models in the China National Knowledge Network and PubMed until July 1,2021,and reviewed six commonly used drug⁃induced depression animal models.The frequency of use of induced depression animal models,selection of model animals,drug injection dosage,injection method,indicators for model evaluation,advantages,and disadvantages are expected to provide references to prepare depression models and develop drugs.

关 键 词：抑郁症 药物诱导 药理模型 

分 类 号：R-33[医药卫生]