不可逆电穿孔肿瘤消融技术的过去和现在  

Past and Present of Irreversible Electroporation for Tumor Ablation

作　　者：包家立 陈新华[2,3] BAO Jiali;CHEN Xinhua(Research Team of Biophysics and Medical Engineering,Zhejiang Provincial Key Laboratory of Bioelectromagnetics,School of Medicine,Zhejiang University,Hangzhou Zhejiang 310058,China;Division of Hepatobiliary and Pancreatic Surgery,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou Zhejiang 310003,China;Zhejiang Provincial Key Laboratory of Pulsed Power Translational Medicine,Hangzhou Zhejiang 311100,China)

机构地区：[1]浙江大学医学院浙江省生物电磁学重点实验室生物物理与医学工程研究组,浙江杭州310058 [2]浙江大学医学院附属第一医院肝胆胰外科,浙江杭州310003 [3]浙江省脉冲电场技术医学转化重点实验室,浙江杭州311100

出　　处：《中国医疗设备》2023年第5期1-10,30,共11页China Medical Devices

基　　金：国家科技重大专项课题(2018ZX10301201-002)。

摘　　要：不可逆电穿孔(Irreversible Electroporation,IRE)是在脉冲电场作用下,细胞膜脂质双分子层或生物组织产生不可逆亲水性孔道的现象,其生物效应为使细胞产生凋亡或死亡。2021年,国家药监局批准了2个国产IRE设备上市。至今,这个技术已经在国内多家医院进行了肝癌、胰腺癌、前列腺癌等的临床治疗应用,取得良好的治疗效果。本文综述了IRE肿瘤消融技术的国内外发展情况,从其发展脉络展望未来发展方向。Irreversible electroporation(IRE)is a phenomenon in which irreversible hydrophilic pores are generated in the lipid bilayer of cell membrane or biological tissue under the action of pulsed electric field,and its biological effect is to cause cell apoptosis or death.In 2021,the National Food and Drug Administration approved the marketing of two domestic IRE devices.So far,this technology has been applied in many domestic hospitals for the clinical treatment of liver cancer,pancreatic cancer,prostate cancer and so on,and achieved good therapeutic effect.This paper reviews the past and present of IRE at home and abroad,and looks forward to the future development of this technique.

关 键 词：不可逆电穿孔 纳秒脉冲电场 肿瘤 消融技术 

分 类 号：R730.5[医药卫生—肿瘤] R197.39[医药卫生—临床医学]