Eff ects of continuous renal replacement therapy on infl ammation-related anemia, iron metabolism and prognosis in sepsis patients with acute kidney injury  

作　　者：Meng-meng An Chen-xi Liu Ping Gong 

机构地区：[1]Intensive Care Unit,the Affi liated Dalian Friendship Hospital of Dalian Medical University,Dalian 116100,China [2]Department of Emergency Medicine,the First Affi liated Hospital of Dalian Medical University,Dalian 116011,China [3]Department of Emergency Medicine,Shenzhen People's Hospital(the Second Clinical Medical College of Jinan University,the First Affi liated Hospital of Southern University of Science and Technology),Shenzhen 518020,China

出　　处：《World Journal of Emergency Medicine》2023年第3期186-192,共7页世界急诊医学杂志（英文）

基　　金：funded by the Shenzhen Key Medical Discipline Construction Fund(S ZXK046);the National Nature Science Foundation of China(81571869).

摘　　要：BACKGROUND:This study aims to evaluate the eff ect of continuous renal replacement therapy(CRRT)on inflammation-related anemia,iron metabolism,and the prognosis in sepsis patients with acute kidney injury(AKI).METHODS:Sepsis patients with AKI were prospectively enrolled and randomized into the CRRT and control groups.The clinical and laboratory data on days 1,3 and 7 after intensive care unit(ICU)admission were collected.The serum interleukin(IL)-6,hepcidin,erythropoietin,ferritin,and soluble transferrin receptor(sTfR)were determined by enzyme-linked immunosorbent assay.The Sequential Organ Failure Assessment(SOFA)score and 28-day mortality were recorded.Data were analyzed using Pearson’s Chi-square test or Fisher’s exact test(categorical variables),and Mann-Whitney U-test or t-test(continuous variables).RESULTS:The hemoglobin and serum erythropoietin levels did not signifi cantly diff er between the CRRT and control groups though gradually decreased within the first week of ICU admission.On days 3 and 7,the serum IL-6,hepcidin,ferritin,and red blood cell distribution width significantly decreased in the CRRT group compared to the control group(all P<0.05).On day 7,the serum iron was significantly elevated in the CRRT group compared to the control group(P<0.05).However,the serum sTfR did not signifi cantly diff er between the groups over time.In addition,the SOFA scores were signifi cantly lower in the CRRT group compared to the control group on day 7.The 28-day mortality did not signifi cantly diff er between the control and CRRT groups(38.0%vs.28.2%,P=0.332).CONCLUSION:CRRT might have beneficial effects on the improvement in inflammationrelated iron metabolism and disease severity during the fi rst week of ICU admission but not anemia and 28-day mortality in sepsis patients with AKI.

关 键 词：SEPSIS Continuous renal replacement therapy Acute kidney injury ANEMIA Iron metabolism 

分 类 号：R459.7[医药卫生—急诊医学] R692[医药卫生—治疗学]