安脑片联合奥拉西坦治疗脑卒中后血管性痴呆热毒内盛证临床研究  

Clinical Study on Annao Tablets Combined with Oxiracetam for Vascular DementiaAfter Stroke with Internal Exuberance of Heat Toxin Syndrome

作　　者：黄平香[1] 毛平安[1] 方彩莲[1] 姚建亮 HUANG Pingxiang;MAO Ping'an;FANG Cailian;YAO Jianliang

机构地区：[1]丽水市人民医院康复医学科,浙江丽水323000

出　　处：《新中医》2023年第8期48-52,共5页New Chinese Medicine

摘　　要：目的:观察安脑片联合奥拉西坦治疗脑卒中后血管性痴呆(VD)热毒内盛证的临床疗效。方法:按随机数字表法将100例脑卒中后VD热毒内盛证患者分为治疗组与对照组,每组50例。对照组采用奥拉西坦治疗,治疗组给予安脑片联合奥拉西坦治疗,2组均治疗4周。比较2组临床疗效与不良反应发生率。采用美国国立卫生研究院卒中量表(NIHSS)、简易智能精神状态检查量表(MMSE)、临床痴呆评定量表(CDR)、日常生活活动能力量表(ADL)评估神经功能、认知功能、痴呆程度和日常生活活动能力;比较双侧大脑中动脉(MCA)、基底动脉(BA)、大脑前动脉(ACA)、椎动脉(VA)平均血流速度,以及血清脑源性神经营养因子(BDNF)、血管内皮生长因子(VEGF)水平。结果:治疗后,治疗组临床疗效总有效率96.00%,高于对照组82.00%(P<0.05)。治疗后,2组NIHSS、CDR评分均较治疗前降低(P<0.05),MMSE、ADL评分均较治疗前升高(P<0.05);治疗组NIHSS、CDR评分均低于对照组(P<0.05),MMSE、ADL评分均高于对照组(P<0.05)。治疗后,2组BA、MCA、VA、ACA血流速度均较治疗前升高(P<0.05),治疗组BA、MCA、VA、ACA血流速度均高于对照组(P<0.05)。治疗后,2组血清BDNF、VEGF水平均较治疗前升高(P<0.05),治疗组BDNF、VEGF水平均高于对照组(P<0.05)。治疗期间,治疗组不良反应发生率10.00%,与对照组8.00%比较,差异无统计学意义(P>0.05)。结论:在奥拉西坦治疗脑卒中后VD热毒内盛证基础上加用安脑片可提高临床疗效,促进患者认知功能及神经功能恢复,提升其脑血流速度和血清BDNF、VEGF水平,改善其生活质量,不良反应少。Objective:To observe the clinical effect of Annao Tablets combined with Oxiracetam on vascular dementia(VD)after stroke with internal exuberance of heat toxin syndrome.Methods:A total of 100 patients of VD after stroke with internal exuberance of heat toxin syndrome were selected and divided into the treatment group and the control group according to the random number table method,with 50 cases in each group.The control group was treated with Oxiracetam,and the treatment group was treated with Annao Tablets combined with Oxiracetam.Both groups were treated for 4 weeks.The clinical effects and incidence of adverse reactions were compared between the two groups.The neurological function,cognitive function,degree of dementia and activitees of daily living were evaluated by National Institutes of Health Stroke Scale(NIHSS),Mini-Mental State Examination(MMSE),Clinical Dementia Rating(CDR)and Activities of Daily Living(ADL);the mean blood velocity of bilateral middle cerebral artery (MCA),basilar artery (BA),anterior cerebral artery (ACA) and vertebral artery (VA),as well as the levels ofserum brain- derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) werecompared. Results:After treatment,the total clinical effective rate was 96.00% in the treatment group,higher than that of 82.00% in the control group (P<0.05). After treatment,the scores of NIHSS and CDRwere decreased when compared with those before treatment (P<0.05),and the scores of MMSE and ADLwere increased compared with those before treatment (P<0.05);the scores of NIHSS and CDR in thetreatment group were lower than those in the control group (P<0.05),and the scores of MMSE and ADLwere higher than those in the control group (P<0.05). After treatment,the blood velocity of BA,MCA,VAand ACA in the two groups were increased when compared with those before treatment (P<0.05),and theblood velocity of BA, MCA, VA and ACA in the treatment group were higher than those in the controlgroup (P<0.05). After treatment,the levels of serum BDNF and

关 键 词：血管性痴呆 脑卒中 热毒内盛证 安脑片 认知功能 神经功能 脑血流速度 生活质量 

分 类 号：R749.13[医药卫生—神经病学与精神病学]