利湿芍药方治疗湿热内蕴证溃疡性结肠炎临床研究  

Clinical Study on Lishi Shaoyao Prescription for Ulcerative Colitis with Internal Accumulation of Damp-Heat Syndrome

作　　者：李月华[1] LI Yuehua

机构地区：[1]遂平县人民医院,河南遂平463000

出　　处：《新中医》2023年第8期58-63,共6页New Chinese Medicine

摘　　要：目的:观察利湿芍药方治疗湿热内蕴证溃疡性结肠炎的临床疗效。方法:将64例湿热内蕴证溃疡性结肠炎患者采用随机数字表法分为2组各32例。对照组给予美沙拉嗪肠溶片口服治疗;治疗组给予利湿芍药方中药口服治疗。用药4周后,评价2组腹泻、黏液便、脓血便、里急后重、腹痛及肛门灼热等临床症状评分,血清炎症因子白细胞介素-6 (IL-6)、白细胞介素-17 (IL-17)、白细胞介素-4 (IL-4)及肿瘤坏死因子-α (TNF-α)的变化情况及Baron内镜评分、Geboes黏膜组织学评分的改善情况。结果:临床疗效总有效率治疗组93.75%,对照组68.75%,2组临床疗效比较,差异有统计学意义(P<0.05)。治疗后,2组临床症状各项评分均较治疗前降低,且治疗组临床症状各项评分均低于对照组(P<0.05)。治疗后,2组炎症因子IL-6、IL-17、TNF-α,以及Baron内镜评分、Geboes评分均降低,IL-4水平升高,差异均有统计学意义(P<0.05)。治疗后,治疗组IL-6、IL-17、TNF-α水平,以及Baron内镜评分、Geboes评分均低于对照组,IL-4水平高于对照组,差异均有统计学意义(P<0.05)。结论:利湿芍药方治疗湿热内蕴证溃疡性结肠炎可有效降低IL-6、IL-17及TNF-α的水平,升高IL-4的水平,缓解炎症进展,缓解肠黏膜溃疡,从而改善腹泻、黏液便、脓血便、里急后重、腹痛及肛门灼热等临床症状。Objective:To observe the clinical effect of Lishi Shaoyao Prescription for ulcerative colitis with internal accumulation of damp-heat syndrome.Methods:A total of 64 cases of patients with ulcerative colitis with internal accumulation of damp-heat syndrome were divided into two groups according to the random number table method,with 32 cases in each group.The control group was treated with the oral administration of Mesalazin Enteric-Coated Tablets,and the treatment group was treated with the oral administration of Lishi Shaoyao Prescription.After 4-week administration,the scores of clinical symptoms including diarrhea,stool with mucus,stool with pus and blood,tenesmus,abdominal pain,and heat scorching the anus,the changes in the serum inflammatory factors including interleukin-6(IL-6),interleukin-17(IL-17),interleukin-4(IL-4),and tumor necrosis factor-α(TNF-α),and the improvement of the Baron Scores for endoscopic grading and the Geboes Scores for mucosal histologic assessment were evaluated in the two groups.Results:The total clinical effective rate was 93.75%in the treatment group and 68.75%in the control group,the difference being significant(P<0.05).After treatment,each score of clinical symptoms in the two groups was decreased when compared with that before treatment,and thescores in the treatment group were lower than those in the control group (P<0.05). After treatment,thelevels of IL- 6,IL- 17,and TNF- α,the Baron Scores,and the Geboes Scores in the two groups weredecreased when compared with those before treatment, and the levels of IL- 4 were increased,differences being significant (P<0.05). After treatment,the levels of IL-6,IL-17,and TNF-α,the BaronScores,and the Geboes Scores in the treatment group were lower than those in the control group,and theIL- 4 level was higher than that in the control group, differences being significant (P<0.05). Conclusion:Lishi Shaoyao Prescription for ulcerative colitis with internal accumulation of damp- heat syndrome caneffectively reduce the levels of IL- 6,IL-17

关 键 词：溃疡性结肠炎 湿热内蕴证 利湿芍药方 炎症因子 Baron内镜评分 Geboes评分 

分 类 号：R574.1[医药卫生—消化系统]