GIST患者Ki67阳性指数与临床病理特征之间的相关性及其预后评估作用  

Correlation Between Ki67 Positive Index and ClinicopathologicalFeatures in GIST Patients and Its Prognostic Evaluation

作　　者：张朝东[1] ZHANG Chaodong(Department of Pathology,The Second People's Hospital of Zhengzhou,Zhengzhou Henan 450052,China)

机构地区：[1]郑州市第二人民医院病理科,河南郑州450052

出　　处：《临床研究》2023年第6期1-4,共4页Clinical Research

摘　　要：目的 分析胃肠道间质瘤(GIST)患者增殖指数(Ki67阳性指数)与临床病理特征之间的相关性及其预后评估作用。方法 采用分层整群抽样法进行抽样调查,抽取2018年1月至2022年12月期间郑州市第二人民医院50例GIST患者作为研究对象,依据患者Ki67指数进行分组,实验1组(17例,Ki67指数<1%),实验2组(17例,Ki67指数1%~5%),实验3组(16例,Ki67指数> 5%),对所有研究对象临床资料进行收集,对比三组阳性占比差异、病理特征差异、预后差异,将有差异项采用Logistic回归方程进行计算,分析Ki67阳性指数与临床病理特征之间的相关性。结果 实验1组阳性2例(4.18%)、实验2组阳性7例(41.18%)、实验3组阳性15例(93.75%),组间对比差异有统计学意义(P <0.05);实验1组、实验2组、实验3组性别、年龄、肿瘤直径、远处转移、肿瘤部位方面数据对比差异无统计学意义(P> 0.05),在淋巴转移、TNM分期方面差异有统计学意义(P <0.05);Ki67阳性指数与GIST淋巴转移、TNM分期均呈正相关(P <0.05),与肿瘤直径、远处转移、肿瘤部位无明显相关性(P> 0.05);实验1组预后良好15例(88.24%)、复发2例(4.18%);实验2组预后良好8例(47.06%)、复发9例(52.94%);实验3组预后良好3例(18.75%)、复发3例(81.25%),组间对比差异有统计学意义(P <0.05)。结论 GIST患者Ki67阳性指数与病理特征(淋巴转移、TNM分期)呈正相关,即Ki67阳性指数越高则淋巴转移风险越大、TNM分期越高,同时研究表明Ki67阳性指数与GIST患者预后密切相关,指数高者预后差,在GIST诊疗过程中可选择性应用Ki67阳性指数对疾病进行评估。Objective To analyze the correlation between the proliferation index(Ki67 positive index)and clinicopathologic features in patients with gastrointestinal stromal tumors(GIST)and its prognostic evaluation.Methods A stratified cluster sampling method was adopted to conduct a sampling survey,and 50 GIST patients from the Second People's Hospital of Zhengzhou from January 2018 to December 2022 were selected as research objects.According to the Ki67 index of patients,the patients were divided into three groups:experimental group 1(17 cases,Ki67 index<1%)and experimental group 2(17 cases,Ki67 index 1%-5%),3 experimental groups(16 cases,Ki67 index>5%).The clinical data of all subjects were collected,and the difference in positive ratio,pathological features,and prognosis of the three groups was compared.The differences were calculated by the Logistic regression equation,and the correlation between Ki67 positive index and clinicopathological features was analyzed.Results There were 2 positive cases(4.18%)in experimental group 1,7 positive cases(41.18%)in experimental group 2,and 15 positive cases(93.75%)in experimental group 3.The difference between groups was statistically significant(P<0.05).There were no significant differences in gender,age,tumor diameter,distant metastasis,and tumor site in experimental group 1,experimental group 2,and experimental group 3(P>0.05),but there were significant differences in lymphatic metastasis and TNM staging(P<0.05).Ki67 positive index was positively correlated with GIST lymphatic metastasis and TNM staging(P<0.05)but had no significant correlation with tumor diameter,distant metastasis,and tumor location(P>0.05).In experiment group 1,15 cases(88.24%)had a good prognosis and 2 cases(4.18%)had relapsed.In experimental group 2,8 patients(47.06%)had a good prognosis,and 9 patients(52.94%)had relapse.In experimental group 3,there were 3 cases with good prognosis(18.75%)and 3 cases with recurrence(81.25%),and the difference between groups was statistically significant(P<0.05).Conclusion

关 键 词：胃肠道间质瘤 增殖指数 病理特征 预后评估 

分 类 号：R735.2[医药卫生—肿瘤]