血管内皮生长因子和肿瘤标志物对肺癌分期的诊断价值分析  

Diagnostic Value of Vascular Endothelial Growth Factor and Tumor Markers in Staging of Lung Cancer

作　　者：樊宁 FAN Ning(Department of Pathology,Luoyang Central Hospital,Luoyang Henan 471000,China)

机构地区：[1]洛阳市中心医院病理科,河南洛阳471000

出　　处：《临床研究》2023年第6期10-13,共4页Clinical Research

摘　　要：目的 探讨血管内皮生长因子(VEGF)和肿瘤标志物对肺癌分期的诊断价值。方法 临床研究选取2021年1月至2022年10月在洛阳市中心医院接受诊治的68例肺癌患者为研究组,按照患者肿瘤原发灶情况(TNM)将其分为Ⅰ~Ⅱ期(N=22),Ⅲ~Ⅳ期(N=26),末期(N=20),并按照病理将肺癌患者分为腺癌28例,鳞癌16例,大细胞癌10例,小细胞癌8例以及未分型6例,另外选取在本院进行体检的50例健康志愿者作为对照组。对所有患者血清VEGF指标和肿瘤标志物进行检测,观察肺癌患者、健康志愿者、不同肺癌分期患者和不同病理类型患者血清VEGF与肿瘤标志物指标,以及血清VEGF和肿瘤标志物与淋巴结、胸膜转移关系。结果 研究组血清VEGF、癌胚抗原(CEA)、糖类抗原125(CA125)、细胞角蛋白19片段(CYFRA21-1)、神经元特异性烯醇化酶(NSE)指标高于对照组,差异有统计学意义(P <0.05)。检测结果表明三组肺癌患者血清VEGF指标对比,Ⅰ~Ⅱ期低于Ⅲ~Ⅳ期低于末期,而CEA、CA125、CYFRA21-1、NSE指标Ⅲ~Ⅳ期高于Ⅰ~Ⅱ期和末期,差异有统计学意义(P <0.05)。腺癌患者血清VEGF、CEA、CA125、CYFRA21-1、NSE显著高于其他类型患者,差异有统计学意义(P <0.05)。有、无淋巴结转移情况患者血清VEGF、CEA及细胞角蛋白19片段(CYFRA21-1)水平基本相同,差异无统计学意义(P> 0.05),但有胸水患者血清VEGF、CEA及CYFRA21-1水平显著高于无胸水患者,差异有统计学意义(P <0.05)。结论 针对肺癌患者通过检测血清VEGF及肿瘤标志物,不仅有利于患者肺癌、不同病理类型肺癌诊断以及为胸膜发生转移提供依据,更有利于对患者肺癌分期进行诊断,对肺癌患者分期的诊断具有临床应用价值。Objective To investigate the diagnostic value of vascular endothelial growth factor(VEGF)and tumor markers in the staging of lung cancer.Methods A total of 68 patients with lung cancer who were treated in Luoyang Central Hospital from January 2021 to October 2022 were selected as the study group.According to the primary tumor(TNM),the patients were divided into stageⅠ~Ⅱ(N=22),stageⅢ~Ⅳ(N=26),and terminal stage(N=20).According to pathology,the patients with lung cancer were divided into adenocarcinoma(28 cases),squamous cell carcinoma(16 cases),large cell carcinoma(10 cases),small cell carcinoma(8 cases),and unclassified(6 cases).In addition,50 healthy volunteers who underwent physical examination in our hospital were selected as the control group.Serum VEGF indexes and tumor markers were detected in all patients,and the relationship between serum VEGF and tumor markers in patients with lung cancer,healthy volunteers,patients with different stages of lung cancer,and patients with different pathological types,as well as correlations of serum VEGF and tumor markers and lymph node and pleural metastasis,was observed.Results The serum indexes of VEGF,carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),cytokeratin 19 fragments(CYFRA21-1),and neuron-specific enolase(NSE)in the study group were higher than those in the control group,and the difference was statistically significant(P<0.05).The results showed that the serum VEGF index of stageⅠtoⅡwas lower than that of stageⅢtoⅣ,while the CEA,CA125,CYFRA21-1,NSE index of stageⅢtoⅣwas higher than that of stageⅠtoⅡand the late stage,and the difference was statistically significant(P<0.05).Serum VEGF,CEA,CA125,CYFRA21-1,and NSE in adenocarcinoma patients were significantly higher than those in other types of patients,with statistical significance(P<0.05).The serum levels of VEGF,CEA,and CYFRA21-1 in patients with and without lymph node metastasis were almost the same,and the difference was not statistically significant(P>0.05).However,the seru

关 键 词：血管内皮生长因子 肿瘤标志物 肺癌分期 诊断价值 

分 类 号：R734.2[医药卫生—肿瘤]