丁苯酞氯化钠注射液联合阿司匹林、阿托伐他汀钙及桂哌齐特治疗急性脑梗死伴认知功能障碍患者的疗效评价  

Evaluation of the Efficacy of Butylphthalide Sodium Chloride Injection combined with Aspirin,Atorvastatin Calcium,and Cinepazide in the Treatment of acute cerebral Infarction Patients with cognitive Impairment

作　　者：刘冠雄 朱风俊[1] 徐明超[1] 樊书领[1] 金鑫 贾东佩[1] LIU Guanxiong;ZHU Fengjun;XU Mingchao;FAN Shuling;JIN Xin;JIA Dongpei(Department of Neurology,Nanyang Central Hospital,Nanyang Henan 473000,China)

机构地区：[1]南阳市中心医院神经内科,河南南阳473000

出　　处：《临床研究》2023年第6期46-49,共4页Clinical Research

摘　　要：目的 分析丁苯酞氯化钠注射液加阿司匹林、阿托伐他汀钙及桂哌齐特对急性脑梗死(ACI)伴认知功能障碍的疗效。方法 选取2021年6月2022年6月南阳市中心医院收治的86例ACI伴认知障碍患者,经随机数字表法分成对照组(使用阿司匹林、阿托伐他汀钙和桂哌齐特)、观察组(于对照组组基础上加以丁苯酞氯化钠注射液),各43例,比较两组治疗有效率、治疗前后神经功能缺损评分(NIHSS)、日常生活能力评分(ADL)、简易精神状态表评分(MMSE)、脑血流量(CBF)、脑血容量(CBV)及平均通过时间(MTT),并统计副反应发生率。结果 观察组治疗有效率高于对照组,差异有统计学意义(P <0.05)。治疗前,两组NIHSS、ADL及MMSE评分相比,差异无统计学意义(P> 0.05);治疗后,两组NIHSS评分均低于治疗前,ADL及MMSE评分均高于治疗前,且观察组NIHSS评分较对照组显著降低,ADL及MMSE评分高于对照组,差异有统计学意义(P <0.05)。治疗前,两组CBF、CBV、MTT相比,差异无统计学意义(P> 0.05);治疗后,两组CBF、CBV均多于治疗前,MTT短于治疗前,且观察组CBF、CBV高于对照组,MTT短于对照组,差异有统计学意义(P <0.05)。两组副反应发生率相比,差异无统计学意义(P> 0.05)。结论 丁苯酞氯化钠注射液加阿司匹林、阿托伐他汀钙及桂哌齐特对ACI伴认知障碍疗效确切,能缓解患者的神经缺损,提升其生活能力,改善其认知功能和脑部血流灌注,且不会显著增加副反应,安全性较高,值得临床应用。Objective To analyze the efficacy of sodium chloride injection of butylphthalide combined with aspirin,atorvastatin calcium,and cinepazide in the treatment of acute cerebral infarction(ACI)with cognitive impairment.Methods A total of 86 patients with ACI and cognitive impairment admitted to Nanyang Central Hospital from June 2021 to June 2022 were divided into a control group(using aspirin,atorvastatin calcium,and cinepazide)and an observation group(adding sodium chloride injection of butylphthalide on the basis of control group)according to the random number table,with 43 patients in each group.The treatment efficacy,neurological deficit score(NIHSS)before and after treatment,daily living ability score(ADL),minimum-mental state examination(MMSE),cerebral blood flow(CBF),cerebral blood volume(CBV),and mean transit time(MTT)were compared between the two groups,and the incidence of side effects were calculated.Results The effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in NIHSS,ADL,and MMSE scores between the two groups(P>0.05);After treatment,the NIHSS scores of both groups were lower than before treatment,while the ADL and MMSE scores were higher than before treatment.The NIHSS scores of the observation group were significantly lower than those of the control group,and the ADL and MMSE scores were higher than those of the control group,with a statistically significant difference(P<0.05).Before treatment,there was no statistically significant difference in CBF,CBV,and MTT between the two groups(P>0.05);After treatment,the CBF and CBV in both groups were higher than before treatment,and the MTT was shorter than before treatment. The CBF and CBV in the observation group were higher than those in the control group, and theMTT was shorter than that in the control group, with a statistically significant difference (P < 0.05). There was no statisticall

关 键 词：丁苯酞 阿司匹林 桂哌齐特 阿托伐他汀钙 急性脑梗死 认知功能障碍 

分 类 号：R743.33[医药卫生—神经病学与精神病学]