Geranylated or prenylated flavonoids from Cajanus volubilis  

作　　者：RAO Li SU Yu HE Qian YE Jia LIU Yu FAN Yue HU Feng ZHOU Zhen GAN Lishe ZHANG Yonghui ZHANG Chuanrui 

机构地区：[1]Chongqing Key Laboratony of Natural Product Synthesis and Drug Research.School of Pharmaceutical Sciences,Chongqing CUniversily,Chongqing 401331.China [2]School of Biotechnology and Health Sciences,Wuyi Untiversity,Jiangmen,Guangdong 529020.China [3]Chongqing Key Laboratory of Development and Utilization of Gencine Medicinal Materials in Three Grorges Resenvoir Area,Chongqing Three Gorges Medical College,Chongqing 404120.China [4]State Key Laboratory of Natural Medicines,China Pharmaceutical Universio,Nanjing 210009,China

出　　处：《Chinese Journal of Natural Medicines》2023年第4期292-297,共6页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.22177016);the Natural Science Foundation of Chongqing(No.cstc2020jcyj-msxmX0537);the Open Project of State Key Laboratory of Natural Medicines(No.SKLNMKF202011).

摘　　要：Five new flavonoid derivatives,cajavolubones A-E(1-5),along with six known analogues(6-11)were isolated from Cajanus volubilis,and their structures were elucidated by spectroscopic analysis and quantum chemical calculations.Cajavolubones A and B(1 and 2)were identified as two geranylated chalcones.Cajavolubone C(3)was a prenylated flavone,while cajavolubones D and E(4 and 5)were two prenylated isoflavanones.Compounds 3,8,9 and 11 displayed cytotoxicity against HCT-116 cancer cell line.

关 键 词：Cajanus volubilis Geranylated chalcone Prenylated flavone Prenylated isoflavanone CYTOTOXICITY 

分 类 号：R284.1[医药卫生—中药学]