细胞因子与精神分裂症机制关联研究进展  

Progress on the study of the correlation between cytokines and pathological mechanism of schizophrenia

作　　者：杨海东 杨曼 潘杨杨 栾凌淑 张晓斌 Yang Haidong;Yang Man;Pan Yangyang;Luan Lingshu;Zhang Xiaobin(Department of Psychiatry,the Fourth People's Hospital of Lianyungang,the Affiliated KangDa College of Nanjing Medical University,Lianyungang 222000,China;Department of Psychiatry,the Affiliated Guangji Hospital of Soochow University,Suzhou 215137,China)

机构地区：[1]南京医科大学康达学院附属连云港第四人民医院精神科,222000 [2]苏州大学附属广济医院精神科,215137

出　　处：《神经疾病与精神卫生》2023年第3期184-188,共5页Journal of Neuroscience and Mental Health

基　　金：江苏省社会发展项目(BE2020764);江苏省卫生健康委员会医学科研项目(H2018041);连云港市卫生健康委员会面上项目(202130);苏州市心境障碍临床医学中心资助项目(Szlcyxzx202109);苏州市重点诊疗项目(LCZX201919)。

摘　　要：精神分裂症是一种严重的致残性精神障碍,其病理生理机制仍不明确,治疗方面存在个体差异及异质性,造成较高的社会、经济负担。本文从多个角度对细胞因子在精神分裂症及其治疗中的变化最新进展进行综述,以期从机制方面理解精神分裂症与细胞因子的关系,为将来从更多维度对精神分裂症病因及个性化治疗提供新的思路。Schizophrenia is a serious disabling mental disorder.Its pathophysiological mechanism is still unclear,and there are individual differences and heterogeneity in treatment,resulting in high social and economic burden.In this paper,we review recent updates on the variations of cytokines in schizophrenia and their therapy from multiple perspective,with the aim of understanding the relationship between schizophrenia and cytokines from the mechanism,and providing new ideas for personalized treatment of schizophrenia patients from a more multidimensional perspective in the future.

关 键 词：精神分裂症 细胞因子 神经炎症 治疗 综述 

分 类 号：R749.3[医药卫生—神经病学与精神病学]