血清EPO、CCCK-18水平与急性脑梗死溶栓后脉血管内支架取栓临床疗效的相关性  

Correlation of Serum EPO and CCCK⁃18 Levels with the Clinical Outcomes of Stent Retriever Thrombectomy in patients with Acute Cerebral Infarction

作　　者：白玉萌 Bai Yumeng(Gongyi People′s Hospital,Zhengzhou,Henan 451200)

机构地区：[1]巩义市人民医院,河南郑州451200

出　　处：《辽宁医学杂志》2023年第2期41-43,共3页Medical Journal of Liaoning

摘　　要：目的分析急性脑梗死患者血清促红细胞生成素(EPO)、部分片段caspase切割的细胞角蛋白18(CCCK-18)水平与动脉血管内支架取栓临床疗效的相关性。方法随机选择医院2018年1月至2021年1月诊治的急性脑梗死患者70例。问卷调查两组患者年龄、性别、高血压病程、出血部位、吸烟史,检测血清EPO、CCCK-18水平。比较两组患者一般资料和血清EPO、CCCK-18水平,分析影响预后的多因素。结果两组患者在年龄、性别、高血压、出血部位、吸烟史比较上无统计学意义(P>0.05)。预后良好组患者血清EPO、CCCK-18水平低于预后不良组(P<0.05)。血清EPO、CCCK-18是影响急性脑梗死预后独立危险因素(P<0.05)。结论急性脑梗死患者血清EPO、CCCK-18水平影响动脉血管内支架取栓临床疗效,其高表达预示预后不良,建议密切关注。Objective To investigate the correlation of serum erythropoietin(EPO)and caspase⁃cleaved cytokeratin⁃18(CCCK⁃18)levels with the clinical outcomes of stent retriever thrombectomy in patients with acute cerebral infarction.Methods Seventy patients with acute cerebral infraction in our hospital from January 2018 to January 2021 were enrolled;Data including age,gender,course of hypertension,bleeding site,smoking history of the patients were investigated by ques⁃tionnaire.Serum EPO and CCCK⁃18 levels were detected.Then the prognostic factors were analyzed.Results Age,gender,hypertension,bleeding site and smoking history showed no significant difference between groups(P>0.05).Serum levels of EPO and CCCK⁃18 in good prognosis group were lower than those in poor prognosis group(P<0.05).Serum EPO and CCCK⁃18 were independent risk factors for prognosis of acute cerebral infarction(P<0.05).Conclusion Serum levels of EPO and CCCK⁃18 have certain impact on the prognosis of patients with acute cerebral infarction undergoing stent retriever thrombectomy,and patients with elevated levels of two indicators may suffer poor prognosis,so the clinical detection is of vi⁃tal importance.

关 键 词：急性脑梗死 EPO CCCK-18 动脉血管内支架取栓 疗效 

分 类 号：R743.33[医药卫生—神经病学与精神病学]