白念珠菌的杂合性丢失事件与抗真菌药物耐药表型相关性研究进展  

Research progress in the relationship between loss of heterozygosity events and antifungal drug resistance in Candida albicans

作　　者：戴榕辰 范欣 江璨然 龚杰 肖盟 季聪华[1] Dai Rongchen;Fan Xin;Jiang Canran;Gong Jie;Xiao Meng;Ji Conghua(College of Public Health,Zhejiang Chinese Medical University,Hangzhou 310053,China;Department of Clinical Microbiology,Institute of Respiratory Medicine and Infectious Diseases,Affiliated Beijing Chaoyang Hospital of Capital Medical University,Beijing 100016,China;Beijing Beinongruiheng Biotechnology Co.,Ltd.,Beijing 102206,China;Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,State Key Laboratory of Infectious Disease Prevention and Control,National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China;Department of Laboratory Medicine,Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China)

机构地区：[1]浙江中医药大学公共卫生学院,杭州310053 [2]首都医科大学附属北京朝阳医院呼吸医学与传染病研究所,临床微生物学系,北京100016 [3]北京北农瑞恒生物科技有限责任公司,北京102206 [4]中国疾病预防控制中心传染病预防控制所,传染病预防控制国家重点实验室,感染性疾病诊治协同创新中心,北京102206 [5]中国医学科学院北京协和医院检验科,侵袭性真菌病机制研究与精准诊断北京市重点实验室,北京100730

出　　处：《中华微生物学和免疫学杂志》2023年第4期309-315,共7页Chinese Journal of Microbiology and Immunology

摘　　要：作为具有重要临床意义的病原体, 白念珠菌可以在人体多个生态位上广泛定植, 尤其会对免疫功能低下的人群产生严重的后果。目前能够使用的抗真菌药物非常有限, 然而白念珠菌的基因组又具有较高的变异性, 可以帮助其快速适应抗真菌药物带来的压力。因此, 该物种的耐药问题仍是威胁临床的巨大隐患。本研究重点关注白念珠菌频繁发生的杂合性丢失(loss of heterozygosity, LOH)事件, 总结了LOH与白念珠菌其他基因组变异形式之间的关联, 并从新发突变频率、耐药基因的纯合性以及生殖方式等方面进一步探讨其与抗真菌药物耐药之间的相关性。Candida albicans as a pathogen of great clinical significance can widely colonize in many ecological niches of human body,especially in the immunocompromised population.Currently,antifungal drugs that can be used in clinical treatment are very limited.However,the genome of Candida albicans has a high rate of mutation,which can help it quickly develop resistance to antifungal drugs.Therefore,drug resistance in Candida albicans remains a great threat to clinical practice.This article focused on the frequent loss of heterozygosity(LOH)events in Candida albicans,summarized the association between LOH and other genomic variants and discussed the relationship of the frequency of de novo mutations,heterozygous status of key drug resistance genes and reproductive pattern with antifungal drug resistance.

关 键 词：真菌 耐药性 杂合性丢失 准性生殖 

分 类 号：R519.3[医药卫生—内科学]