House dust mite allergens and nitrated products: Identification and risk assessment in indoor dust  

作　　者：Fan Xu Jingyi Tian Fangxing Yang 

机构地区：[1]Key Laboratory of Environment Remediation and Ecological Health,Ministry of Education,College of Natural Resources and Environmental Science,Zhejiang University,Hangzhou 310058,China

出　　处：《Journal of Environmental Sciences》2023年第2期198-204,共7页环境科学学报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China (No. 41977341);Natural Science Foundation of Zhejiang Province, China (No. LGF21B070007);Research Center for Air Pollution and Health, Zhejiang University (No. I21405-11)

摘　　要：Air pollutants can potentially lead to nitration of allergic proteins,thus promoting sensitization of these allergens.However,little is currently known about the nitration status of house dust mite(HDM)allergens.We identified the occurrence of nitrated products of two major HDM allergens Der f 1 and Der p 1 in dust samples collected from college dormitories in eastern China and assessed their associated health risk.The results showed that both non-nitrated and nitrated forms of the two allergens were detected in the dust in the range of non-detected(ND)-10.6,1.44-15.4,ND-22.4,ND-7.28μg/g for non-nitrated Der f 1,nitrated Der f 1,non-nitrated Der p 1 and nitrated Der p 1,respectively.The median rates of nitration were determined as 74.0%for Der f 1 and 20.4% for Der p 1 at consideration of one nitration site.Further analysis reveals that the levels of HDM allergens and their nitrated products were found to be generally higher during winter,in dormitories of lower altitude and with female occupants.Furthermore,the calculated risk indexes were at considerably high levels.Our findings suggest that nitrated HDM allergens have already accumulated in the environment at such significant levels and their associated health risk calls for our immediate attention.

关 键 词：ALLERGEN Air pollution Health risk House dust mite(HDM) NITRATION 

分 类 号：X51[环境科学与工程—环境工程] X820.4