Zn^(2+) loading as a critical contributor to the circ_0008553-mediated oxidative stress and inflammation in response to PM_(2.5) exposures  

作　　者：Jingzhou Wang Jianbo Jia Dujia Wang Xiujiao Pan Haiyan Xiong Chengjun Li Yiguo Jiang Bing Yan 

机构地区：[1]Institute of Environmental Research at Greater Bay Area,Key Laboratory for Water Quality and Conservation of the Pearl River Delta,Ministry of Education,Guangzhou University,Guangzhou 510006,China [2]School of Environmental Science and Engineering,Shandong University,Qingdao 266237,China [3]Institute for Chemical Carcinogenesis,Guangzhou Medical University,Guangzhou 511436,China

出　　处：《Journal of Environmental Sciences》2023年第2期451-461,共11页环境科学学报（英文版）

基　　金：supported by the National Natural Science Foundation of China (Nos.22036002,21906035 and 91643204);the National Key Research&Development Program of China(No.2016YFA0203103);the introduced innovative R&D team project under the“The Pearl River Talent Recruitment Program”of Guangdong Province (No.2019ZT08L387)

摘　　要：Inflammation is a major adverse outcome induced by inhaled particulate matter with a diameter of≤2.5μm(PM_(2.5)),and a critical trigger ofmost PM_(2.5) exposure-associated diseases.However,the key molecular events regulating the PM_(2.5)-induced airway inflammation are yet to be elucidated.Considering the critical role of circular RNAs(circRNAs)in regulating inflammation,we predicted 11 circRNAs that may be involved in the PM_(2.5)-induced airway inflammation using three previously reportedmiRNAs through the starBasewebsite.A novel circRNA circ_0008553 was identified to be responsible for the PM_(2.5)-activated inflammatory response in human bronchial epithelial cells(16HBE)via inducing oxidative stress.Using a combinatorial model PM_(2.5) library,we found that the synergistic effect of the insoluble core and loaded Zn^(2+)ions at environmentally relevant concentrations was the major contributor to the upregulation of circ_0008553 and subsequent induction of oxidative stress and inflammation in response to PM2.5 exposures.Our findings provided new insight into the intervention of PM_(2.5)-induced adverse outcomes.

关 键 词：PM(2.5) Toxic composition Combinatorial model PM_(2.5)library Circ_0008553 INFLAMMATION 

分 类 号：X513[环境科学与工程—环境工程]